A practical look at the chemistry and biology of hydrogen sulfide

Research output: Contribution to journalReview article

141 Scopus citations

Abstract

Significance: Hydrogen sulfide (H2S) is garnering increasing interest as a biologically relevant signaling molecule. The effects of H 2S have now been observed in virtually every organ system and numerous physiological processes. Recent Advances: These studies have not only opened a new field of "gasotransmitter" biology, they have also led to the development of synthetic H2S "donating" compounds with the potential to be parlayed into a variety of therapeutic applications. Critical Issues: Often lost in the exuberance of this new field is a critical examination or understanding of practical aspects of H2S chemistry and biology. This is especially notable in the areas of handling and measuring H2S, evaluating biosynthetic and metabolic pathways, and separating physiological from pharmacological responses. Future Directions: This brief review describes some of the pitfalls in H2S chemistry and biology that can lead or have already led to misleading or erroneous conclusions. The intent is to allow individuals entering or already in this burgeoning field to critically analyze the literature and to assist them in the design of future experiments.

Original languageEnglish (US)
Pages (from-to)32-44
Number of pages13
JournalAntioxidants and Redox Signaling
Volume17
Issue number1
DOIs
StatePublished - Jul 1 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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