A primary linkage map of the human chromosome 11q22-23 region

Patrick Charmley, Tatiana Foroud, Shan Wei, Patrick Concannon, Daniel E. Weeks, Kenneth Lange, Richard A. Gatti

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We have constructed a genetic map of the human chromosomal region 11q22-23 by multipoint linkage analysis of 13 DNA polymorphisms that we have condensed into eight loci. An analysis for linkage disequilibrium between tightly linked probe/enzyme systems allows us to make specific recommendations for future DNA typing at these loci. The resulting sex-averaged multipoint map spans approximately 80 cM and differs considerably from previously reported genetic maps of this region. Our mathematically derived "most likely order" of the markers is compatible with physical mapping data using somatic cell hybrids. The known localizations of at least 14 functional genes and several disease loci to 11q22-23, including ataxia telangiectasia, make the mapping of this region especially relevant to studies of disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)316-323
Number of pages8
JournalGenomics
Volume6
Issue number2
DOIs
StatePublished - Feb 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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