A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: The need for a uniform approach

Peter Pang, John G F Cleland, John R. Teerlink, Sean P. Collins, Christopher J. Lindsell, George Sopko, W. Frank Peacock, Gregg C. Fonarow, Amer Z. Aldeen, J. Douglas Kirk, Alan B. Storrow, Miguel Tavares, Alexandre Mebazaa, Edmond Roland, Barry M. Massie, Alan S. Maisel, Michel Komajda, Gerasimos Filippatos, Mihai Gheorghiade

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Dyspnoea is the most common presenting symptom amongst patients with acute heart failure syndromes (AHFS). It is distressing to patients and therefore an important target for treatment in clinical practice, clinical trials, and for regulatory approval of novel agents. Despite its importance as a treatment target, no consensus exists on how to assess dyspnoea in this setting. There is a considerable uncertainty about the reproducibility of the various instruments used to measure dyspnoea, their ability to reflect changes in symptoms and whether they accurately reflect the patient's experience. Little attempt has been made to ensure consistent implementation with respect to patients' posture during assessment or timing in relationship to therapy. There is also limited understanding of how rapidly and completely dyspnoea responds to standard therapy. A standardized method with which to assess dyspnoea is required for clinical trials of AHFS in order to ensure uniform collection of data on a key endpoint. We propose the Provocative Dyspnoea Assessment, a method of measurement that combines sequential dyspnoea provocation by positioning and walking with a dyspnoea self assessment using a five-point Likert scale, to yield a final Dyspnoea Severity Score. This proposed tool requires detailed validation but has face validity for the uniform assessment of dyspnoea.

Original languageEnglish (US)
Pages (from-to)816-824
Number of pages9
JournalEuropean Heart Journal
Volume29
Issue number6
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Dyspnea
Heart Failure
Clinical Trials
Aptitude
Therapeutics
Posture
Reproducibility of Results
Walking
Uncertainty
Consensus

Keywords

  • Clinical trials
  • Dyspnoea
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes : The need for a uniform approach. / Pang, Peter; Cleland, John G F; Teerlink, John R.; Collins, Sean P.; Lindsell, Christopher J.; Sopko, George; Peacock, W. Frank; Fonarow, Gregg C.; Aldeen, Amer Z.; Kirk, J. Douglas; Storrow, Alan B.; Tavares, Miguel; Mebazaa, Alexandre; Roland, Edmond; Massie, Barry M.; Maisel, Alan S.; Komajda, Michel; Filippatos, Gerasimos; Gheorghiade, Mihai.

In: European Heart Journal, Vol. 29, No. 6, 03.2008, p. 816-824.

Research output: Contribution to journalArticle

Pang, P, Cleland, JGF, Teerlink, JR, Collins, SP, Lindsell, CJ, Sopko, G, Peacock, WF, Fonarow, GC, Aldeen, AZ, Kirk, JD, Storrow, AB, Tavares, M, Mebazaa, A, Roland, E, Massie, BM, Maisel, AS, Komajda, M, Filippatos, G & Gheorghiade, M 2008, 'A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: The need for a uniform approach', European Heart Journal, vol. 29, no. 6, pp. 816-824. https://doi.org/10.1093/eurheartj/ehn048
Pang, Peter ; Cleland, John G F ; Teerlink, John R. ; Collins, Sean P. ; Lindsell, Christopher J. ; Sopko, George ; Peacock, W. Frank ; Fonarow, Gregg C. ; Aldeen, Amer Z. ; Kirk, J. Douglas ; Storrow, Alan B. ; Tavares, Miguel ; Mebazaa, Alexandre ; Roland, Edmond ; Massie, Barry M. ; Maisel, Alan S. ; Komajda, Michel ; Filippatos, Gerasimos ; Gheorghiade, Mihai. / A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes : The need for a uniform approach. In: European Heart Journal. 2008 ; Vol. 29, No. 6. pp. 816-824.
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