A prospective study of telomere length and the risk of skin cancer

Jiali Han, Abrar A. Qureshi, Jennifer Prescott, Qun Guo, Li Ye, David J. Hunter, Immaculata De Vivo

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Telomere length is important in tumorigenesis. Using quantitative real-time PCR, we prospectively measured relative telomere length in a nested case-control study within the Nurses' Health Study: 218 melanoma cases, 285 squamous-cell carcinoma (SCC) cases, 300 basal-cell carcinoma (BCC) cases, and 870 controls. We observed that shorter telomeres were associated with a decreased number of moles (P=0.002) and a decreased risk of melanoma. Women in the second and first quartiles, those with the shortest telomere length, had an odds ratio (OR) for melanoma of 0.54 (95% confidence interval (CI), 0.29-1.01) and 0.59 (95% CI, 0.31-1.13), respectively, compared with those in the fourth quartile (P, trend=0.09). There was no clear trend between telomere length and SCC risk. In contrast, we found that shorter telomere length was associated with an increased risk of BCC. Compared with those in the fourth quartile, women in the first quartile had an OR of 1.85 (95% CI, 0.94-3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalJournal of Investigative Dermatology
Volume129
Issue number2
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

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Telomere
Skin Neoplasms
Skin
Prospective Studies
Melanoma
Basal Cell Carcinoma
Confidence Intervals
Squamous Cell Carcinoma
Odds Ratio
Cells
Health
Case-Control Studies
Real-Time Polymerase Chain Reaction
Carcinogenesis
Nurses
Epithelial Cells
Research

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Han, J., Qureshi, A. A., Prescott, J., Guo, Q., Ye, L., Hunter, D. J., & De Vivo, I. (2009). A prospective study of telomere length and the risk of skin cancer. Journal of Investigative Dermatology, 129(2), 415-421. https://doi.org/10.1038/jid.2008.238

A prospective study of telomere length and the risk of skin cancer. / Han, Jiali; Qureshi, Abrar A.; Prescott, Jennifer; Guo, Qun; Ye, Li; Hunter, David J.; De Vivo, Immaculata.

In: Journal of Investigative Dermatology, Vol. 129, No. 2, 01.02.2009, p. 415-421.

Research output: Contribution to journalArticle

Han, J, Qureshi, AA, Prescott, J, Guo, Q, Ye, L, Hunter, DJ & De Vivo, I 2009, 'A prospective study of telomere length and the risk of skin cancer', Journal of Investigative Dermatology, vol. 129, no. 2, pp. 415-421. https://doi.org/10.1038/jid.2008.238
Han, Jiali ; Qureshi, Abrar A. ; Prescott, Jennifer ; Guo, Qun ; Ye, Li ; Hunter, David J. ; De Vivo, Immaculata. / A prospective study of telomere length and the risk of skin cancer. In: Journal of Investigative Dermatology. 2009 ; Vol. 129, No. 2. pp. 415-421.
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