A prospective surgical pathological study of stage I squamous carcinoma of the cervix

A Gynecologic Oncology Group study

G. Delgado, B. N. Bundy, W. C. Fowler, Frederick Stehman, B. Sevin, William T. Creasman, F. Major, P. DiSaia, R. Zaino

Research output: Contribution to journalArticle

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Abstract

Thirty-three institutions collaborating in the Gynecologic Oncology Group gathered surgical and pathological data on 1125 patients with primary, previously untreated, histologically confirmed stage I cervical carcinoma with more than 3 mm of invasion who were selected to undergo radical hysterectomy and paraaortic and pelvic lymphadenectomy. Of the 940 eligible, evaluable patients, 732 had squamous carcinoma. Of the study group, 87 (12%) did not undergo radical hysterectomy because of gross disease beyond the uterus or microscopic aortic node involvement documented at exploratory laparotomy. Among the 645 patients undergoing pelvic and paraaortic lymphadenectomy and radical hysterectomy, five risk factors were significantly associated with microscopic pelvic lymph node metastasis: depth of invasion (P = 0.0001), parametrial involvement (P = 0.0001), capillary-lymphatic space invasion (P = 0.0001), tumor grade (P = 0.01), and gross versus occult primary tumor (P = 0.009). The factors identified as independent risk factors for pelvic lymph node metastasis by multivariate analysis were capillary-lymphatic space involvement (P < 0.0001), depth of invasion (P < 0.0001), parametrial involvement (P = 0.0005), and age (P = 0.02). The model was used to predict the chance of a patient having nodal metastasis for any combination of risk factors.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalGynecologic Oncology
Volume35
Issue number3
DOIs
StatePublished - 1989

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Cervix Uteri
Squamous Cell Carcinoma
Hysterectomy
Lymphatic Vessels
Neoplasm Metastasis
Lymph Node Excision
Lymph Nodes
Laparotomy
Uterus
Neoplasms
Multivariate Analysis
Carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

A prospective surgical pathological study of stage I squamous carcinoma of the cervix : A Gynecologic Oncology Group study. / Delgado, G.; Bundy, B. N.; Fowler, W. C.; Stehman, Frederick; Sevin, B.; Creasman, William T.; Major, F.; DiSaia, P.; Zaino, R.

In: Gynecologic Oncology, Vol. 35, No. 3, 1989, p. 314-320.

Research output: Contribution to journalArticle

Delgado, G. ; Bundy, B. N. ; Fowler, W. C. ; Stehman, Frederick ; Sevin, B. ; Creasman, William T. ; Major, F. ; DiSaia, P. ; Zaino, R. / A prospective surgical pathological study of stage I squamous carcinoma of the cervix : A Gynecologic Oncology Group study. In: Gynecologic Oncology. 1989 ; Vol. 35, No. 3. pp. 314-320.
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AU - Major, F.

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