A prospective trial of the effect of vitamin D supplementation on metacarpal bone loss in elderly women

B. E.C. Nordin, M. R. Baker, A. Horsman, M. Peacock

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The effect on cortical bone loss of treating elderly women with 15,000 IU vitamin D2 weekly was evaluated by sequential radiographic morphometry of the metacarpals. One hundred nine randomly selected women aged 65-74 yr were studied for 2 yr. The women were randomly allocated to control or treated groups taking placebo or vitamin D2 capsules. Hand radiographs and blood samples were obtained at the beginning and end of the trial. Plasma 25-hydroxyvitamin D was measured by radio-competitive protein binding assay. Comparing the treated and control groups, vitamin D treatment significantly raised the plasma 25-hydroxyvitamin D levels (p < 0.001) and reduced the rate of cortical bone loss (p < 0.01). The placebo had no measurable effect on the plasma levels.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume42
Issue number3
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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