A quantitative trait locus for alcohol consumption in selectively bred rat lines

Lucinda G. Carr, Tatiana Foroud, Paula Bice, Troy Gobbett, Julia Ivashina, Howard Edenberg, Lawrence Lumeng, Ting Kai Li

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Selective breeding for high and low alcohol consumption led to the establishment of alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines that differ greatly in their alcohol consumption. These lines were inbred and F2 intercross progenies were generated to detect quantitative trait loci (QTLs)influencing alcohol consumption. A QTL on chromosome 4 was identified with a maximum lod score of 8.6. This QTL acts in an additive fashion and accounts for 11% of the total phenotypic variability and approximately one-third of the genetic variability. Neuropeptide Y, an endogenous anxiolytic and neuromodulator, has been mapped to this same region of chromosome 4. This study is an advance in genome analyses, demonstrating that crosses between divergent, selectively bred rat lines can be used to identify QTLs. Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans.

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number4
StatePublished - 1998

Fingerprint

Quantitative Trait Loci
Alcohol Drinking
Rats
Alcohols
Chromosomes, Human, Pair 4
Alcoholism
Lod Score
Chromosomes
Neuropeptide Y
Anti-Anxiety Agents
Neurotransmitter Agents
Genes
Genome

Keywords

  • Alcoholism
  • Chromosome 4
  • Neuropeptide Y
  • Quantitative Trait Locus (QTL)
  • Rat Lines

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

A quantitative trait locus for alcohol consumption in selectively bred rat lines. / Carr, Lucinda G.; Foroud, Tatiana; Bice, Paula; Gobbett, Troy; Ivashina, Julia; Edenberg, Howard; Lumeng, Lawrence; Li, Ting Kai.

In: Alcoholism: Clinical and Experimental Research, Vol. 22, No. 4, 1998, p. 884-887.

Research output: Contribution to journalArticle

Carr, LG, Foroud, T, Bice, P, Gobbett, T, Ivashina, J, Edenberg, H, Lumeng, L & Li, TK 1998, 'A quantitative trait locus for alcohol consumption in selectively bred rat lines', Alcoholism: Clinical and Experimental Research, vol. 22, no. 4, pp. 884-887.
Carr, Lucinda G. ; Foroud, Tatiana ; Bice, Paula ; Gobbett, Troy ; Ivashina, Julia ; Edenberg, Howard ; Lumeng, Lawrence ; Li, Ting Kai. / A quantitative trait locus for alcohol consumption in selectively bred rat lines. In: Alcoholism: Clinical and Experimental Research. 1998 ; Vol. 22, No. 4. pp. 884-887.
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