A radiographic comparison of erosive osteoarthritis and idiopathic nodal osteoarthritis

D. Smith, E. M. Braunstein, K. D. Brandt, Barry Katz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Clinical, radiographic and histologic features suggest that inflammation is central to the pathogenesis of erosive osteoarthritis (OA). Since mediators of inflammation may activate osteoclasts and stimulate release of metalloproteinases in joint cartilage, we hypothesized that patients with erosive OA may have more joint space narrowing and less proliferative bone response (osteophytes, sclerosis) than those with idiopathic nodal OA. Hand radiographs of 33 patients with erosive OA and 33 age and sex matched patients with nodal OA were evaluated for prevalence and severity of joint space narrowing, osteophytes, subchondral sclerosis, subchondral cysts, erosions and subchondral collapse. While the prevalence and severity of OA was greater at each joint in erosive OA than in nodal OA, significant differences (p < 0.05) were confined largely to the interphalangeal joints. Among patients with erosive OA, radiographic features of OA were more severe in joints with erosive changes than in joints that did not show erosive change (p < 0.01 in most cases). Notably, when joints with erosive change were excluded, only joint space narrowing was more severe in patients with erosive OA than in the corresponding joints of patients with nodal OA (p < 0.001). Our analysis did not support the hypothesis that inflammatory mediators modify chondro or osteoneogenesis in erosive OA.

Original languageEnglish
Pages (from-to)896-904
Number of pages9
JournalJournal of Rheumatology
Volume19
Issue number6
StatePublished - 1992

Fingerprint

Osteoarthritis
Joints
Osteophyte
Sclerosis
Bone Cysts
Inflammation Mediators
Metalloproteases
Osteoclasts
Cartilage
Hand
Inflammation
Bone and Bones

Keywords

  • erosive osteoarthritis
  • heberden's nodes
  • nodal osteoarthritis
  • osteoarthritis
  • radiographic features of osteoarthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

A radiographic comparison of erosive osteoarthritis and idiopathic nodal osteoarthritis. / Smith, D.; Braunstein, E. M.; Brandt, K. D.; Katz, Barry.

In: Journal of Rheumatology, Vol. 19, No. 6, 1992, p. 896-904.

Research output: Contribution to journalArticle

Smith, D. ; Braunstein, E. M. ; Brandt, K. D. ; Katz, Barry. / A radiographic comparison of erosive osteoarthritis and idiopathic nodal osteoarthritis. In: Journal of Rheumatology. 1992 ; Vol. 19, No. 6. pp. 896-904.
@article{58981645a0e14fd28e9969a9f9566556,
title = "A radiographic comparison of erosive osteoarthritis and idiopathic nodal osteoarthritis",
abstract = "Clinical, radiographic and histologic features suggest that inflammation is central to the pathogenesis of erosive osteoarthritis (OA). Since mediators of inflammation may activate osteoclasts and stimulate release of metalloproteinases in joint cartilage, we hypothesized that patients with erosive OA may have more joint space narrowing and less proliferative bone response (osteophytes, sclerosis) than those with idiopathic nodal OA. Hand radiographs of 33 patients with erosive OA and 33 age and sex matched patients with nodal OA were evaluated for prevalence and severity of joint space narrowing, osteophytes, subchondral sclerosis, subchondral cysts, erosions and subchondral collapse. While the prevalence and severity of OA was greater at each joint in erosive OA than in nodal OA, significant differences (p < 0.05) were confined largely to the interphalangeal joints. Among patients with erosive OA, radiographic features of OA were more severe in joints with erosive changes than in joints that did not show erosive change (p < 0.01 in most cases). Notably, when joints with erosive change were excluded, only joint space narrowing was more severe in patients with erosive OA than in the corresponding joints of patients with nodal OA (p < 0.001). Our analysis did not support the hypothesis that inflammatory mediators modify chondro or osteoneogenesis in erosive OA.",
keywords = "erosive osteoarthritis, heberden's nodes, nodal osteoarthritis, osteoarthritis, radiographic features of osteoarthritis",
author = "D. Smith and Braunstein, {E. M.} and Brandt, {K. D.} and Barry Katz",
year = "1992",
language = "English",
volume = "19",
pages = "896--904",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "6",

}

TY - JOUR

T1 - A radiographic comparison of erosive osteoarthritis and idiopathic nodal osteoarthritis

AU - Smith, D.

AU - Braunstein, E. M.

AU - Brandt, K. D.

AU - Katz, Barry

PY - 1992

Y1 - 1992

N2 - Clinical, radiographic and histologic features suggest that inflammation is central to the pathogenesis of erosive osteoarthritis (OA). Since mediators of inflammation may activate osteoclasts and stimulate release of metalloproteinases in joint cartilage, we hypothesized that patients with erosive OA may have more joint space narrowing and less proliferative bone response (osteophytes, sclerosis) than those with idiopathic nodal OA. Hand radiographs of 33 patients with erosive OA and 33 age and sex matched patients with nodal OA were evaluated for prevalence and severity of joint space narrowing, osteophytes, subchondral sclerosis, subchondral cysts, erosions and subchondral collapse. While the prevalence and severity of OA was greater at each joint in erosive OA than in nodal OA, significant differences (p < 0.05) were confined largely to the interphalangeal joints. Among patients with erosive OA, radiographic features of OA were more severe in joints with erosive changes than in joints that did not show erosive change (p < 0.01 in most cases). Notably, when joints with erosive change were excluded, only joint space narrowing was more severe in patients with erosive OA than in the corresponding joints of patients with nodal OA (p < 0.001). Our analysis did not support the hypothesis that inflammatory mediators modify chondro or osteoneogenesis in erosive OA.

AB - Clinical, radiographic and histologic features suggest that inflammation is central to the pathogenesis of erosive osteoarthritis (OA). Since mediators of inflammation may activate osteoclasts and stimulate release of metalloproteinases in joint cartilage, we hypothesized that patients with erosive OA may have more joint space narrowing and less proliferative bone response (osteophytes, sclerosis) than those with idiopathic nodal OA. Hand radiographs of 33 patients with erosive OA and 33 age and sex matched patients with nodal OA were evaluated for prevalence and severity of joint space narrowing, osteophytes, subchondral sclerosis, subchondral cysts, erosions and subchondral collapse. While the prevalence and severity of OA was greater at each joint in erosive OA than in nodal OA, significant differences (p < 0.05) were confined largely to the interphalangeal joints. Among patients with erosive OA, radiographic features of OA were more severe in joints with erosive changes than in joints that did not show erosive change (p < 0.01 in most cases). Notably, when joints with erosive change were excluded, only joint space narrowing was more severe in patients with erosive OA than in the corresponding joints of patients with nodal OA (p < 0.001). Our analysis did not support the hypothesis that inflammatory mediators modify chondro or osteoneogenesis in erosive OA.

KW - erosive osteoarthritis

KW - heberden's nodes

KW - nodal osteoarthritis

KW - osteoarthritis

KW - radiographic features of osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=0026627983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026627983&partnerID=8YFLogxK

M3 - Article

C2 - 1404126

AN - SCOPUS:0026627983

VL - 19

SP - 896

EP - 904

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 6

ER -