A radioimmunoassay for serum calcitonin in the rat

N. H. Bell, Sherry Queener

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A radioimmunoassay for serum calcitonin in the rat is described. Materials for assay of human calcitonin are employed. The sensitivity of the assay is 3 pg and corresponds to a lower limit of detection of 60 pg/ml for peripheral serum. The normal range is up to 650 pg/ml in rats weighing between 125 and 200 g. Serum calcitonin is not detectable in thyroparathyroidectomized animals. It increases and varies directly with the serum calcium after intraperitoneal administration of the ion. Values for serum calcitonin in male and female rats are comparable under basal conditions and after calcium. The radioimmunoassay should allow the further characterization of calcitonin secretion in response to physiologic and pathophysiologic stimuli in this species.

Original languageEnglish
Pages (from-to)516-519
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume152
Issue number4
StatePublished - 1976

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Calcitonin
Radioimmunoassay
Rats
Serum
Assays
Calcium
Weighing
Limit of Detection
Reference Values
Animals
Ions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A radioimmunoassay for serum calcitonin in the rat. / Bell, N. H.; Queener, Sherry.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 152, No. 4, 1976, p. 516-519.

Research output: Contribution to journalArticle

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