A randomized, controlled trial of catheter-related infectious event rates using antibiotic-impregnated catheters versus conventional catheters in pediatric cardiovascular surgery patients

Elaine Cox, Chad A. Knoderer, Aimee Jennings, John Brown, Mark Rodefeld, Scott Walker, Mark Turrentine

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We conducted a randomized, controlled clinical trial to determine whether a difference in catheterassociated blood stream infection (CABSI) incidence existed between children who underwent cardiac surgery and had a central venous catheter impregnated with minocycline and rifampin versus those who had a conventional, nonimpregnated catheter after cardiac surgery. Due to a lower number of infections than expected, the study was terminated early. Among 288 evaluable patients, the rates of CABSI and line-related complications were similar between the 2 groups.

Original languageEnglish (US)
Article numberpis066
Pages (from-to)67-70
Number of pages4
JournalJournal of the Pediatric Infectious Diseases Society
Volume2
Issue number1
DOIs
StatePublished - 2013

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Catheters
Randomized Controlled Trials
Pediatrics
Anti-Bacterial Agents
Thoracic Surgery
Infection
Minocycline
Central Venous Catheters
Rifampin
Incidence

ASJC Scopus subject areas

  • Infectious Diseases
  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "We conducted a randomized, controlled clinical trial to determine whether a difference in catheterassociated blood stream infection (CABSI) incidence existed between children who underwent cardiac surgery and had a central venous catheter impregnated with minocycline and rifampin versus those who had a conventional, nonimpregnated catheter after cardiac surgery. Due to a lower number of infections than expected, the study was terminated early. Among 288 evaluable patients, the rates of CABSI and line-related complications were similar between the 2 groups.",
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AU - Rodefeld, Mark

AU - Walker, Scott

AU - Turrentine, Mark

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