A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea

Ripudaman S. Beniwal, Vincent C. Arena, Leno Thomas, Sudhir Narla, Thomas F. Imperiale, Rauf A. Chaudhry, Usman A. Ahmad

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrheal days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

Original languageEnglish (US)
Pages (from-to)2077-2082
Number of pages6
JournalDigestive diseases and sciences
Volume48
Issue number10
DOIs
StatePublished - Oct 1 2003

Keywords

  • Antibiotic-associated diarrhea
  • Biotherapeutics
  • Dietary intervention
  • Effectiveness
  • Prophylaxis
  • Yogurt

ASJC Scopus subject areas

  • Gastroenterology

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    Beniwal, R. S., Arena, V. C., Thomas, L., Narla, S., Imperiale, T. F., Chaudhry, R. A., & Ahmad, U. A. (2003). A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea. Digestive diseases and sciences, 48(10), 2077-2082. https://doi.org/10.1023/A:1026155328638