A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea

Ripudaman S. Beniwal, Vincent C. Arena, Leno Thomas, Sudhir Narla, Thomas Imperiale, Rauf A. Chaudhry, Usman A. Ahmad

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrheal days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

Original languageEnglish
Pages (from-to)2077-2082
Number of pages6
JournalDigestive Diseases and Sciences
Volume48
Issue number10
DOIs
StatePublished - Oct 2003

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Yogurt
Diarrhea
Anti-Bacterial Agents
Dietary Supplements
Compliance
Age Groups
Incidence
Therapeutics

Keywords

  • Antibiotic-associated diarrhea
  • Biotherapeutics
  • Dietary intervention
  • Effectiveness
  • Prophylaxis
  • Yogurt

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Beniwal, R. S., Arena, V. C., Thomas, L., Narla, S., Imperiale, T., Chaudhry, R. A., & Ahmad, U. A. (2003). A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea. Digestive Diseases and Sciences, 48(10), 2077-2082. https://doi.org/10.1023/A:1026155328638

A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea. / Beniwal, Ripudaman S.; Arena, Vincent C.; Thomas, Leno; Narla, Sudhir; Imperiale, Thomas; Chaudhry, Rauf A.; Ahmad, Usman A.

In: Digestive Diseases and Sciences, Vol. 48, No. 10, 10.2003, p. 2077-2082.

Research output: Contribution to journalArticle

Beniwal, RS, Arena, VC, Thomas, L, Narla, S, Imperiale, T, Chaudhry, RA & Ahmad, UA 2003, 'A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea', Digestive Diseases and Sciences, vol. 48, no. 10, pp. 2077-2082. https://doi.org/10.1023/A:1026155328638
Beniwal, Ripudaman S. ; Arena, Vincent C. ; Thomas, Leno ; Narla, Sudhir ; Imperiale, Thomas ; Chaudhry, Rauf A. ; Ahmad, Usman A. / A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea. In: Digestive Diseases and Sciences. 2003 ; Vol. 48, No. 10. pp. 2077-2082.
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