A randomized trial to increase physical activity in breast cancer survivors

Laura Q. Rogers, Patricia Hopkins-Price, Sandy Vicari, Richard Pamenter, Kerry S. Courneya, Stephen Markwell, Steven Verhulst, Karen Hoelzer, Catherine Naritoku, Linda Jones, Gary Dunnington, Victor Lanzotti, James Wynstra, Lisa Shah, Billie Edson, Ashleigh Graff, Michelle Lowy

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Purpose: Interventions to increase physical activity among breast cancer survivors are needed to improve health and quality of life and possibly to reduce the risk of disease recurrence and early mortality. Therefore, we report the feasibility and preliminary outcomes of a pilot randomized trial designed to increase physical activity in sedentary breast cancer survivors receiving hormone therapy. Methods: Forty-one sedentary women on estrogen receptor modulators or aromatase inhibitors for stage I, II, or IIIA breast cancer were randomly assigned to receive a 12-wk multidisciplinary physical activity behavior change intervention or usual care. Results: Recruitment was 34%, intervention adherence was 99%, and complete follow-up data were obtained on 93%. Most participants (93%) were white with mean age of 53 ± 9 yr. Differences favoring the intervention group were noted for accelerometer physical activity counts (mean difference = 72,103; 95% confidence interval (CI) = 25,383-119,000; effect size (d) = 1.02; P = 0.004), aerobic fitness (mean difference = 2.9; 95% CI = -0.1 to 5.8; d = 0.64; P = 0.058), back/leg muscle strength (mean difference = 12.3; 95% CI = 0.4-15.9; d = 0.81; P = 0.017), waist-to-hip ratio (mean difference = -0.05; 95% CI = -0.01 to -0.08; d = -0.77; P = 0.018), and social well-being (mean difference = 2.0; 95% CI = 0.3-3.8; d = 0.76; P = 0.03). However, the intervention group also reported a greater increase in joint stiffness (mean difference = 1.1; 95% CI = 0.1-2.2; d = 0.70; P = 0.04). Conclusions: A behavior change intervention for breast cancer survivors based on the social cognitive theory is feasible and results in potentially meaningful improvements in physical activity and selected health outcomes. Confirmation in a larger study is warranted.

Original languageEnglish (US)
Pages (from-to)935-946
Number of pages12
JournalMedicine and Science in Sports and Exercise
Volume41
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Survivors
Confidence Intervals
Exercise
Breast Neoplasms
Back Muscles
Aromatase Inhibitors
Estrogen Receptor Modulators
Waist-Hip Ratio
Health
Muscle Strength
Leg
Joints
Quality of Life
Hormones
Recurrence
Mortality

Keywords

  • Body composition
  • Exercise
  • Intervention
  • Oncology
  • Prevention
  • Survivorship

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Rogers, L. Q., Hopkins-Price, P., Vicari, S., Pamenter, R., Courneya, K. S., Markwell, S., ... Lowy, M. (2009). A randomized trial to increase physical activity in breast cancer survivors. Medicine and Science in Sports and Exercise, 41(4), 935-946. https://doi.org/10.1249/MSS.0b013e31818e0e1b

A randomized trial to increase physical activity in breast cancer survivors. / Rogers, Laura Q.; Hopkins-Price, Patricia; Vicari, Sandy; Pamenter, Richard; Courneya, Kerry S.; Markwell, Stephen; Verhulst, Steven; Hoelzer, Karen; Naritoku, Catherine; Jones, Linda; Dunnington, Gary; Lanzotti, Victor; Wynstra, James; Shah, Lisa; Edson, Billie; Graff, Ashleigh; Lowy, Michelle.

In: Medicine and Science in Sports and Exercise, Vol. 41, No. 4, 04.2009, p. 935-946.

Research output: Contribution to journalArticle

Rogers, LQ, Hopkins-Price, P, Vicari, S, Pamenter, R, Courneya, KS, Markwell, S, Verhulst, S, Hoelzer, K, Naritoku, C, Jones, L, Dunnington, G, Lanzotti, V, Wynstra, J, Shah, L, Edson, B, Graff, A & Lowy, M 2009, 'A randomized trial to increase physical activity in breast cancer survivors', Medicine and Science in Sports and Exercise, vol. 41, no. 4, pp. 935-946. https://doi.org/10.1249/MSS.0b013e31818e0e1b
Rogers LQ, Hopkins-Price P, Vicari S, Pamenter R, Courneya KS, Markwell S et al. A randomized trial to increase physical activity in breast cancer survivors. Medicine and Science in Sports and Exercise. 2009 Apr;41(4):935-946. https://doi.org/10.1249/MSS.0b013e31818e0e1b
Rogers, Laura Q. ; Hopkins-Price, Patricia ; Vicari, Sandy ; Pamenter, Richard ; Courneya, Kerry S. ; Markwell, Stephen ; Verhulst, Steven ; Hoelzer, Karen ; Naritoku, Catherine ; Jones, Linda ; Dunnington, Gary ; Lanzotti, Victor ; Wynstra, James ; Shah, Lisa ; Edson, Billie ; Graff, Ashleigh ; Lowy, Michelle. / A randomized trial to increase physical activity in breast cancer survivors. In: Medicine and Science in Sports and Exercise. 2009 ; Vol. 41, No. 4. pp. 935-946.
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