A rare case of thyroid storm

Brock McMillen, Manvinder Shelley Dhillon, Sabrina Yong-Yow

Research output: Contribution to journalArticle

27 Scopus citations


Thyroid storm is a rare and life-threatening state of thyroid hormone excess. Rapid recognition of thyroid storm is key to decreasing the morbidity and mortality of this condition. Clinical manifestations of thyroid storm include unexplained weight loss, hyperactivity and irritability. The most common causes of thyrotoxicosis are Graves' disease, toxic multinodular goitre and toxic adenoma. We present a rare case of thyroid storm induced by dual nivolumab and ipilimumab immunotherapy in a patient receiving treatment for advanced melanoma. In this case, our patient was admitted for thyroid storm 1 month after initiating treatment with nivolumab and ipilimumab immunotherapy. The patient was treated with β-blockers, antithyroid medications and systemic steroids resulting in an improvement in thyroid function testing and symptoms.

Original languageEnglish (US)
Article number582
JournalBMJ Case Reports
StatePublished - Apr 18 2016

ASJC Scopus subject areas

  • Medicine(all)

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