A rat model of chronic kidney disease-mineral bone disorder

Sharon M. Moe, Neal X. Chen, Mark F. Seifert, Rachel M. Sinders, Dana Duan, Xianming Chen, Yun Liang, J. Scott Radcliff, Kenneth E. White, Vincent H. Gattone

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components of CKD-MBD when fed a normal phosphorus diet. Since the renal disorder progressed 'naturally' we studied the effect of dietary manipulation during the course of the disease. Animals with early, but established, chronic kidney disease were fed a casein-based or a grain-based protein diet both of which had equivalent total phosphorus contents. The two different sources of dietary protein had profound effects on the progression of CKD-MBD, likely due to differences in intestinal bioavailability of phosphorus. Although both dietary treatments resulted in the same serum phosphorous levels, the casein-fed animals had increased urinary phosphorus excretion and elevated serum FGF23 compared to the grain-fed rats. This model should help identify early changes in the course of chronic kidney disease that may lead to CKD-MBD.

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalKidney international
Volume75
Issue number2
DOIs
StatePublished - Jan 2009

Keywords

  • Chronic kidney disease
  • Hyperparathyroidism
  • Hyperphosphatemia
  • Renal osteodystrophy
  • Vascular calcification

ASJC Scopus subject areas

  • Nephrology

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    Moe, S. M., Chen, N. X., Seifert, M. F., Sinders, R. M., Duan, D., Chen, X., Liang, Y., Radcliff, J. S., White, K. E., & Gattone, V. H. (2009). A rat model of chronic kidney disease-mineral bone disorder. Kidney international, 75(2), 176-184. https://doi.org/10.1038/ki.2008.456