A reappraisal of ventricular fibrillation threshold testing.

Y. M. Cha, B. B. Peters, U. Birgersdotter-Green, P. S. Chen

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

To test the hypothesis that ventricular fibrillation (VF) threshold testing is a probability function, 12 open-chest dogs were studied. The VF thresholds were tested by scanning the T wave with either the single premature stimulus method or with the train stimulus method. The dose-response curve method was used to determine the probability of inducing VF with different strengths of premature stimulation. Conventional methods and up-down methods were also used to test the VF threshold. The results showed that the VF threshold is a probability function. The conventional method VF threshold for the single premature stimulus and for the train stimulus methods corresponded to the current strength associated with a 23.4 +/- 13.2 and a 33.2 +/- 19.5% probability of VF (P < 0.05), respectively. In comparison, the triplicate VF threshold determined by the up-down algorithm method resulted in values that were not significantly different from a 50% probability of inducing VF, with a good correlation (r = 0.90, P < 0.001 for single and r = 0.89, P = 0.003 for the train stimulus method). We conclude that: 1) The VF threshold is a probability function, and 2) the triplicate VF threshold determined by the up-down algorithm method is the best alternative to the dose-response curve method in estimating 50% probability of inducing VF.

Original languageEnglish (US)
Pages (from-to)H1005-1010
JournalThe American journal of physiology
Volume264
Issue number3 Pt 2
DOIs
StatePublished - Mar 1993
Externally publishedYes

ASJC Scopus subject areas

  • Physiology (medical)

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    Cha, Y. M., Peters, B. B., Birgersdotter-Green, U., & Chen, P. S. (1993). A reappraisal of ventricular fibrillation threshold testing. The American journal of physiology, 264(3 Pt 2), H1005-1010. https://doi.org/10.1152/ajpheart.1993.264.3.h1005