A reappraisal of ventricular fibrillation threshold testing.

Y. M. Cha, B. B. Peters, U. Birgersdotter-Green, Peng-Sheng Chen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To test the hypothesis that ventricular fibrillation (VF) threshold testing is a probability function, 12 open-chest dogs were studied. The VF thresholds were tested by scanning the T wave with either the single premature stimulus method or with the train stimulus method. The dose-response curve method was used to determine the probability of inducing VF with different strengths of premature stimulation. Conventional methods and up-down methods were also used to test the VF threshold. The results showed that the VF threshold is a probability function. The conventional method VF threshold for the single premature stimulus and for the train stimulus methods corresponded to the current strength associated with a 23.4 +/- 13.2 and a 33.2 +/- 19.5% probability of VF (P <0.05), respectively. In comparison, the triplicate VF threshold determined by the up-down algorithm method resulted in values that were not significantly different from a 50% probability of inducing VF, with a good correlation (r = 0.90, P <0.001 for single and r = 0.89, P = 0.003 for the train stimulus method). We conclude that: 1) The VF threshold is a probability function, and 2) the triplicate VF threshold determined by the up-down algorithm method is the best alternative to the dose-response curve method in estimating 50% probability of inducing VF.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume264
Issue number3 Pt 2
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

Ventricular Fibrillation
Thorax
Dogs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cha, Y. M., Peters, B. B., Birgersdotter-Green, U., & Chen, P-S. (1993). A reappraisal of ventricular fibrillation threshold testing. The American journal of physiology, 264(3 Pt 2).

A reappraisal of ventricular fibrillation threshold testing. / Cha, Y. M.; Peters, B. B.; Birgersdotter-Green, U.; Chen, Peng-Sheng.

In: The American journal of physiology, Vol. 264, No. 3 Pt 2, 03.1993.

Research output: Contribution to journalArticle

Cha, YM, Peters, BB, Birgersdotter-Green, U & Chen, P-S 1993, 'A reappraisal of ventricular fibrillation threshold testing.', The American journal of physiology, vol. 264, no. 3 Pt 2.
Cha, Y. M. ; Peters, B. B. ; Birgersdotter-Green, U. ; Chen, Peng-Sheng. / A reappraisal of ventricular fibrillation threshold testing. In: The American journal of physiology. 1993 ; Vol. 264, No. 3 Pt 2.
@article{825805c6407241ff83d033d720ef262d,
title = "A reappraisal of ventricular fibrillation threshold testing.",
abstract = "To test the hypothesis that ventricular fibrillation (VF) threshold testing is a probability function, 12 open-chest dogs were studied. The VF thresholds were tested by scanning the T wave with either the single premature stimulus method or with the train stimulus method. The dose-response curve method was used to determine the probability of inducing VF with different strengths of premature stimulation. Conventional methods and up-down methods were also used to test the VF threshold. The results showed that the VF threshold is a probability function. The conventional method VF threshold for the single premature stimulus and for the train stimulus methods corresponded to the current strength associated with a 23.4 +/- 13.2 and a 33.2 +/- 19.5{\%} probability of VF (P <0.05), respectively. In comparison, the triplicate VF threshold determined by the up-down algorithm method resulted in values that were not significantly different from a 50{\%} probability of inducing VF, with a good correlation (r = 0.90, P <0.001 for single and r = 0.89, P = 0.003 for the train stimulus method). We conclude that: 1) The VF threshold is a probability function, and 2) the triplicate VF threshold determined by the up-down algorithm method is the best alternative to the dose-response curve method in estimating 50{\%} probability of inducing VF.",
author = "Cha, {Y. M.} and Peters, {B. B.} and U. Birgersdotter-Green and Peng-Sheng Chen",
year = "1993",
month = "3",
language = "English (US)",
volume = "264",
journal = "American Journal of Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "3 Pt 2",

}

TY - JOUR

T1 - A reappraisal of ventricular fibrillation threshold testing.

AU - Cha, Y. M.

AU - Peters, B. B.

AU - Birgersdotter-Green, U.

AU - Chen, Peng-Sheng

PY - 1993/3

Y1 - 1993/3

N2 - To test the hypothesis that ventricular fibrillation (VF) threshold testing is a probability function, 12 open-chest dogs were studied. The VF thresholds were tested by scanning the T wave with either the single premature stimulus method or with the train stimulus method. The dose-response curve method was used to determine the probability of inducing VF with different strengths of premature stimulation. Conventional methods and up-down methods were also used to test the VF threshold. The results showed that the VF threshold is a probability function. The conventional method VF threshold for the single premature stimulus and for the train stimulus methods corresponded to the current strength associated with a 23.4 +/- 13.2 and a 33.2 +/- 19.5% probability of VF (P <0.05), respectively. In comparison, the triplicate VF threshold determined by the up-down algorithm method resulted in values that were not significantly different from a 50% probability of inducing VF, with a good correlation (r = 0.90, P <0.001 for single and r = 0.89, P = 0.003 for the train stimulus method). We conclude that: 1) The VF threshold is a probability function, and 2) the triplicate VF threshold determined by the up-down algorithm method is the best alternative to the dose-response curve method in estimating 50% probability of inducing VF.

AB - To test the hypothesis that ventricular fibrillation (VF) threshold testing is a probability function, 12 open-chest dogs were studied. The VF thresholds were tested by scanning the T wave with either the single premature stimulus method or with the train stimulus method. The dose-response curve method was used to determine the probability of inducing VF with different strengths of premature stimulation. Conventional methods and up-down methods were also used to test the VF threshold. The results showed that the VF threshold is a probability function. The conventional method VF threshold for the single premature stimulus and for the train stimulus methods corresponded to the current strength associated with a 23.4 +/- 13.2 and a 33.2 +/- 19.5% probability of VF (P <0.05), respectively. In comparison, the triplicate VF threshold determined by the up-down algorithm method resulted in values that were not significantly different from a 50% probability of inducing VF, with a good correlation (r = 0.90, P <0.001 for single and r = 0.89, P = 0.003 for the train stimulus method). We conclude that: 1) The VF threshold is a probability function, and 2) the triplicate VF threshold determined by the up-down algorithm method is the best alternative to the dose-response curve method in estimating 50% probability of inducing VF.

UR - http://www.scopus.com/inward/record.url?scp=0027566619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027566619&partnerID=8YFLogxK

M3 - Article

VL - 264

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0193-1857

IS - 3 Pt 2

ER -