A remote system for the synthesis of copper-62 labeled Cu(PTSM)

Carla J. Mathias, William H. Margenau, James W. Brodack, Michael J. Welch, Mark A. Green

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The construction and performance of a remote system is described for the synthesis of 62Cu-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II), [62Cu]Cu(PTSM), a positron-emitting radiopharmaceutical for perfusion imaging. The remote system allows the shielded synthesis and purification of tracer using the 2 M HCl eluate of high-level (10-18 GBq)62Zn/62Cu radionuclide generator system. The remote system allows the [62Cu]Cu(PTSM) synthesis to be performed in under 8 min with ca 40% E.O.S. radiochemical yield and >98% radiochemical purity.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume42
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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