A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States

John B. Buse, Patrizia Cavazzoni, Kenneth Hornbuckle, David Hutchins, Alan Breier, Lois Jovanovic

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Treatment-emergent diabetes mellitus (DM) has been described for conventional and atypical antipsychotics. In our study, antipsychotic prescription claims from AdvancePCS's database were used to identify patients starting antipsychotic monotherapy. The relative risk of developing DM was determined using prescription claims for antidiabetic agents in the following cohorts: AdvancePCS general patient population, combined conventional antipsychotics, and combined atypical antipsychotics. Cox proportional hazards regression was used to adjust for differences in age, gender, and duration of antipsychotic exposure between cohorts in the estimation of risk of developing diabetes. Hazard ratios for developing DM in the combined conventional, combined atypical, and individual conventional and atypical antipsychotic treatment cohorts were greater than the AdvancePCS general patient population cohort. An increased risk of developing diabetes compared with the AdvancePCS general patient population was observed during treatment with conventional or atypical antipsychotics.

Original languageEnglish (US)
Pages (from-to)164-170
Number of pages7
JournalJournal of Clinical Epidemiology
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2003

Fingerprint

Antipsychotic Agents
Diabetes Mellitus
Cohort Studies
Retrospective Studies
Therapeutics
Prescriptions
Population
Hypoglycemic Agents
Databases

Keywords

  • Antipsychotics
  • Diabetes
  • Epidemiologic study

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States. / Buse, John B.; Cavazzoni, Patrizia; Hornbuckle, Kenneth; Hutchins, David; Breier, Alan; Jovanovic, Lois.

In: Journal of Clinical Epidemiology, Vol. 56, No. 2, 01.02.2003, p. 164-170.

Research output: Contribution to journalArticle

Buse, John B. ; Cavazzoni, Patrizia ; Hornbuckle, Kenneth ; Hutchins, David ; Breier, Alan ; Jovanovic, Lois. / A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States. In: Journal of Clinical Epidemiology. 2003 ; Vol. 56, No. 2. pp. 164-170.
@article{37ae250bb05e4ea3b34cbcc6bdb6c80d,
title = "A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States",
abstract = "Treatment-emergent diabetes mellitus (DM) has been described for conventional and atypical antipsychotics. In our study, antipsychotic prescription claims from AdvancePCS's database were used to identify patients starting antipsychotic monotherapy. The relative risk of developing DM was determined using prescription claims for antidiabetic agents in the following cohorts: AdvancePCS general patient population, combined conventional antipsychotics, and combined atypical antipsychotics. Cox proportional hazards regression was used to adjust for differences in age, gender, and duration of antipsychotic exposure between cohorts in the estimation of risk of developing diabetes. Hazard ratios for developing DM in the combined conventional, combined atypical, and individual conventional and atypical antipsychotic treatment cohorts were greater than the AdvancePCS general patient population cohort. An increased risk of developing diabetes compared with the AdvancePCS general patient population was observed during treatment with conventional or atypical antipsychotics.",
keywords = "Antipsychotics, Diabetes, Epidemiologic study",
author = "Buse, {John B.} and Patrizia Cavazzoni and Kenneth Hornbuckle and David Hutchins and Alan Breier and Lois Jovanovic",
year = "2003",
month = "2",
day = "1",
doi = "10.1016/S0895-4356(02)00588-7",
language = "English (US)",
volume = "56",
pages = "164--170",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States

AU - Buse, John B.

AU - Cavazzoni, Patrizia

AU - Hornbuckle, Kenneth

AU - Hutchins, David

AU - Breier, Alan

AU - Jovanovic, Lois

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Treatment-emergent diabetes mellitus (DM) has been described for conventional and atypical antipsychotics. In our study, antipsychotic prescription claims from AdvancePCS's database were used to identify patients starting antipsychotic monotherapy. The relative risk of developing DM was determined using prescription claims for antidiabetic agents in the following cohorts: AdvancePCS general patient population, combined conventional antipsychotics, and combined atypical antipsychotics. Cox proportional hazards regression was used to adjust for differences in age, gender, and duration of antipsychotic exposure between cohorts in the estimation of risk of developing diabetes. Hazard ratios for developing DM in the combined conventional, combined atypical, and individual conventional and atypical antipsychotic treatment cohorts were greater than the AdvancePCS general patient population cohort. An increased risk of developing diabetes compared with the AdvancePCS general patient population was observed during treatment with conventional or atypical antipsychotics.

AB - Treatment-emergent diabetes mellitus (DM) has been described for conventional and atypical antipsychotics. In our study, antipsychotic prescription claims from AdvancePCS's database were used to identify patients starting antipsychotic monotherapy. The relative risk of developing DM was determined using prescription claims for antidiabetic agents in the following cohorts: AdvancePCS general patient population, combined conventional antipsychotics, and combined atypical antipsychotics. Cox proportional hazards regression was used to adjust for differences in age, gender, and duration of antipsychotic exposure between cohorts in the estimation of risk of developing diabetes. Hazard ratios for developing DM in the combined conventional, combined atypical, and individual conventional and atypical antipsychotic treatment cohorts were greater than the AdvancePCS general patient population cohort. An increased risk of developing diabetes compared with the AdvancePCS general patient population was observed during treatment with conventional or atypical antipsychotics.

KW - Antipsychotics

KW - Diabetes

KW - Epidemiologic study

UR - http://www.scopus.com/inward/record.url?scp=0037297466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037297466&partnerID=8YFLogxK

U2 - 10.1016/S0895-4356(02)00588-7

DO - 10.1016/S0895-4356(02)00588-7

M3 - Article

VL - 56

SP - 164

EP - 170

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

IS - 2

ER -