A retrospective survey of endocardial proliferative lesions in rats.

M. N. Novilla, George Sandusky, D. M. Hoover, S. E. Ray, K. A. Wightman

Research output: Contribution to journalArticle

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Abstract

Sixty, proliferative, endocardial lesions were diagnosed in 19,304 rats, for an overall incidence of 0.3%. This population consisted of 10,127 Fischer 344, 8,737 Wistar, 200 Sprague-Dawley, and 240 Long Evans rats from chronic/oncogenicity studies reported at Lilly Research Laboratories from 1976 to 1988. Of the 60 proliferative lesions, 44 were classified as endocardial hyperplasia, 15 as endocardial schwannomas, and one as an endocardial sarcoma for prevalence rates of 0.2%, 0.08%, and 0.005%, respectively. Affected rats ranged in age from 42 to 110 weeks. There were no sex or treatment-related differences in the prevalence of the rat endocardial proliferative lesions. A review of endocardial lesions in 18 of 233 Wistar rats treated with carbamate derivatives revealed endocardial hyperplasia in 12 rats, schwannomas in five rats, and a sarcoma in one rat. One of the 12 rats with endocardial hyperplasia also had an intramural schwannoma. Of 200 Wistar rats given N-nitroso-N-methylurea, two had endocardial hyperplasia, and one had an endocardial schwannoma. Morphologic features were similar in either spontaneous or treatment-associated hyperplasia or neoplasia of the rat endocardium. Probable Schwann cell origin of the endocardial proliferative lesions was indicated by positive immunohistochemical staining for S-100 antigen in 10/12 spontaneous and 11/14 carcinogen-associated endocardial hyperplastic lesions. Further, 15/16 spontaneous and 6/7 carcinogen-associated neoplasms were immunoreactive to S-100. No tumor metastasis was recorded in either the spontaneously affected or carcinogen-treated rats.

Original languageEnglish (US)
Pages (from-to)156-165
Number of pages10
JournalVeterinary Pathology
Volume28
Issue number2
StatePublished - Mar 1991
Externally publishedYes

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lesions (animal)
rats
Hyperplasia
Neurilemmoma
hyperplasia
Carcinogens
carcinogens
Sarcoma
Wistar Rats
sarcoma
neoplasms
Surveys and Questionnaires
Endocardium
Neoplasms
Long Evans Rats
Carbamates
S100 Proteins
Schwann Cells
Schwann cells
carcinogenicity

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Novilla, M. N., Sandusky, G., Hoover, D. M., Ray, S. E., & Wightman, K. A. (1991). A retrospective survey of endocardial proliferative lesions in rats. Veterinary Pathology, 28(2), 156-165.

A retrospective survey of endocardial proliferative lesions in rats. / Novilla, M. N.; Sandusky, George; Hoover, D. M.; Ray, S. E.; Wightman, K. A.

In: Veterinary Pathology, Vol. 28, No. 2, 03.1991, p. 156-165.

Research output: Contribution to journalArticle

Novilla, MN, Sandusky, G, Hoover, DM, Ray, SE & Wightman, KA 1991, 'A retrospective survey of endocardial proliferative lesions in rats.', Veterinary Pathology, vol. 28, no. 2, pp. 156-165.
Novilla MN, Sandusky G, Hoover DM, Ray SE, Wightman KA. A retrospective survey of endocardial proliferative lesions in rats. Veterinary Pathology. 1991 Mar;28(2):156-165.
Novilla, M. N. ; Sandusky, George ; Hoover, D. M. ; Ray, S. E. ; Wightman, K. A. / A retrospective survey of endocardial proliferative lesions in rats. In: Veterinary Pathology. 1991 ; Vol. 28, No. 2. pp. 156-165.
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