A review of mouse critical size defect models in weight bearing bones

Jonathan S. Harris, Thomas B. Bemenderfer, Alexander R. Wessel, Melissa Kacena

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Current and future advances in orthopedic treatment are aimed at altering biological interactions to enhance bone healing. Currently, several clinical scenarios exist for which there is no definitive treatment, specifically segmental bone loss from high-energy trauma or surgical resection - and it is here that many are aiming to find effective solutions. To test experimental interventions and better understand bone healing, researchers employ critical size defect (CSD) models in animal studies. Here, an overview of CSDs is given that includes the specifications of varying models, a discussion of current scaffold and bone graft designs, and current outcome measures used to determine the extent of bone healing. Many promising graft designs have been discovered along with promising adjunctive treatments, yet a graft that offers biomechanical support while allowing for neovascularization with eventual complete resorption and remodeling remains to be developed. An overview of this important topic is needed to highlight current advances and provide a clear understanding of the ultimate goal in CSD research - develop a graft for clinical use that effectively treats the orthopedic conundrum of segmental bone loss.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalBone
Volume55
Issue number1
DOIs
StatePublished - Jul 2013

Fingerprint

Weight-Bearing
Bone and Bones
Transplants
Orthopedics
Animal Models
Research Personnel
Outcome Assessment (Health Care)
Wounds and Injuries
Research

Keywords

  • Allograft
  • Autograft
  • Bone healing
  • Critical size defect
  • Mouse model
  • Scaffold

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

A review of mouse critical size defect models in weight bearing bones. / Harris, Jonathan S.; Bemenderfer, Thomas B.; Wessel, Alexander R.; Kacena, Melissa.

In: Bone, Vol. 55, No. 1, 07.2013, p. 241-247.

Research output: Contribution to journalArticle

Harris, Jonathan S. ; Bemenderfer, Thomas B. ; Wessel, Alexander R. ; Kacena, Melissa. / A review of mouse critical size defect models in weight bearing bones. In: Bone. 2013 ; Vol. 55, No. 1. pp. 241-247.
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