A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia

Ian D. Maidment, C. Fox, M. Boustani

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Objective: To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD). Method: MEDLINE (1966 - December 2004), PsychINFO (1972 - December 2004), EMBASE (1980 - December 2004), CINHAL (1982 - December 2004), and the Cochrane Collaboration were searched in December 2004. Results: Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms. Conclusion: Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms - in particular tremor - may limit the utility of cholinesterase inhibitors.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalActa Psychiatrica Scandinavica
Volume111
Issue number6
DOIs
StatePublished - Jun 1 2005

Keywords

  • Cholinesterase inhibitors
  • Parkinson's disease
  • Parkinson's disease dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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