A review of transcriptome analysis in pulmonary vascular diseases

Dustin R. Fraidenburg, Roberto Machado

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transcriptome analysis is a powerful tool in the study of pulmonary vascular disease and pulmonary hypertension. Pulmonary hypertension is a disease process that consists of several unique pathologies sharing a common clinical definition, that of elevated pressure within the pulmonary circulation. As such, it has become increasingly important to identify both similarities and differences among the different classes of pulmonary hypertension. Transcriptome analysis has been an invaluable tool both in the basic science research on animal models as well as clinical research among the various different groups of pulmonary hypertension. This work has identified new potential candidate genes, implicated numerous biochemical and molecular pathways in diseased onset and progression, developed gene signatures to appropriately classify types of pulmonary hypertension and severity of illness, and identified novel gene mutations leading to hereditary forms of the disease.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages259-277
Number of pages19
DOIs
StatePublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1783
ISSN (Print)1064-3745

Fingerprint

Gene Expression Profiling
Vascular Diseases
Pulmonary Hypertension
Lung Diseases
Genes
Inborn Genetic Diseases
Pulmonary Circulation
Research
Disease Progression
Animal Models
Pathology
Pressure
Mutation

Keywords

  • Animal models
  • BMPR2
  • Hereditary pulmonary arterial hypertension
  • Lung disease
  • Pulmonary hypertension
  • Pulmonary vascular disease

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Fraidenburg, D. R., & Machado, R. (2018). A review of transcriptome analysis in pulmonary vascular diseases. In Methods in Molecular Biology (pp. 259-277). (Methods in Molecular Biology; Vol. 1783). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7834-2_13

A review of transcriptome analysis in pulmonary vascular diseases. / Fraidenburg, Dustin R.; Machado, Roberto.

Methods in Molecular Biology. Humana Press Inc., 2018. p. 259-277 (Methods in Molecular Biology; Vol. 1783).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fraidenburg, DR & Machado, R 2018, A review of transcriptome analysis in pulmonary vascular diseases. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1783, Humana Press Inc., pp. 259-277. https://doi.org/10.1007/978-1-4939-7834-2_13
Fraidenburg DR, Machado R. A review of transcriptome analysis in pulmonary vascular diseases. In Methods in Molecular Biology. Humana Press Inc. 2018. p. 259-277. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-7834-2_13
Fraidenburg, Dustin R. ; Machado, Roberto. / A review of transcriptome analysis in pulmonary vascular diseases. Methods in Molecular Biology. Humana Press Inc., 2018. pp. 259-277 (Methods in Molecular Biology).
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