A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps

Thomas Imperiale, Ravi Juluri, Eric A. Sherer, Elizabeth A. Glowinski, Cynthia S. Johnson, Michael S. Morelli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background Predicting the risk of advanced colorectal neoplasia on the second surveillance colonoscopy could help tailor surveillance. Objective To derive and validate a risk index for advanced neoplasia on the second surveillance colonoscopy. Design Retrospective cohort. Setting Single-specialty practice; Veterans Affairs Medical Center. Patients A total of 965 patients with baseline adenomatous polyps, 2 surveillance colonoscopies, and no reported family history of colorectal cancer; validation cohort of 372. Interventions Multivariable logistic regression including demographics and previous colonoscopy results; derivation and validation of a risk index. Main Outcome Measurements Advanced adenoma (≥1 cm in size, villous histology, or high-grade dysplasia) on the second surveillance colonoscopy. Results Mean age was 57.8 ± 9.8 years, 62% were men, and 36% had an advanced adenoma on the index colonoscopy. Associated with advanced adenoma on the second surveillance colonoscopy were age at index colonoscopy (scored 0 for younger than 55 years of age, 1 for 55-59 years of age, 2 for 60-64 years of age, and 3 for older than 65 years of age) and previous findings (non-neoplastic, nonadvanced, advanced [scored 0, 1, and 2, respectively]) on index colonoscopy and the first surveillance colonoscopy, with scores ranging from 1 to 7. Risks of advanced adenoma on the second surveillance colonoscopy with scores of 5 or less and more than 5 were 4.8% (95% confidence interval, 3.5%-6.4%) and 14.9% (95% confidence interval, 7.4%-25.7%), respectively, comprising 93% and 7%, respectively, of the cohort. Corresponding results in the validation cohort were 5.6% and 19.2%, respectively, comprising 86.1% and 13.9%, respectively, of the cohort. Limitations Retrospective study with potential for selection bias. Conclusion This index stratifies the risk of advanced adenoma on the second surveillance colonoscopy. If validated independently, it may be useful for tailoring surveillance.

Original languageEnglish
Pages (from-to)471-478
Number of pages8
JournalGastrointestinal Endoscopy
Volume80
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Adenomatous Polyps
Colonoscopy
Neoplasms
Adenoma
Confidence Intervals
Selection Bias
Veterans
Colorectal Neoplasms
Histology

Keywords

  • Abbreviations
  • CI
  • confidence interval
  • SD
  • standard deviation

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps. / Imperiale, Thomas; Juluri, Ravi; Sherer, Eric A.; Glowinski, Elizabeth A.; Johnson, Cynthia S.; Morelli, Michael S.

In: Gastrointestinal Endoscopy, Vol. 80, No. 3, 2014, p. 471-478.

Research output: Contribution to journalArticle

Imperiale, Thomas ; Juluri, Ravi ; Sherer, Eric A. ; Glowinski, Elizabeth A. ; Johnson, Cynthia S. ; Morelli, Michael S. / A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps. In: Gastrointestinal Endoscopy. 2014 ; Vol. 80, No. 3. pp. 471-478.
@article{11c303bf8152480aa5a0c362c3991c04,
title = "A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps",
abstract = "Background Predicting the risk of advanced colorectal neoplasia on the second surveillance colonoscopy could help tailor surveillance. Objective To derive and validate a risk index for advanced neoplasia on the second surveillance colonoscopy. Design Retrospective cohort. Setting Single-specialty practice; Veterans Affairs Medical Center. Patients A total of 965 patients with baseline adenomatous polyps, 2 surveillance colonoscopies, and no reported family history of colorectal cancer; validation cohort of 372. Interventions Multivariable logistic regression including demographics and previous colonoscopy results; derivation and validation of a risk index. Main Outcome Measurements Advanced adenoma (≥1 cm in size, villous histology, or high-grade dysplasia) on the second surveillance colonoscopy. Results Mean age was 57.8 ± 9.8 years, 62{\%} were men, and 36{\%} had an advanced adenoma on the index colonoscopy. Associated with advanced adenoma on the second surveillance colonoscopy were age at index colonoscopy (scored 0 for younger than 55 years of age, 1 for 55-59 years of age, 2 for 60-64 years of age, and 3 for older than 65 years of age) and previous findings (non-neoplastic, nonadvanced, advanced [scored 0, 1, and 2, respectively]) on index colonoscopy and the first surveillance colonoscopy, with scores ranging from 1 to 7. Risks of advanced adenoma on the second surveillance colonoscopy with scores of 5 or less and more than 5 were 4.8{\%} (95{\%} confidence interval, 3.5{\%}-6.4{\%}) and 14.9{\%} (95{\%} confidence interval, 7.4{\%}-25.7{\%}), respectively, comprising 93{\%} and 7{\%}, respectively, of the cohort. Corresponding results in the validation cohort were 5.6{\%} and 19.2{\%}, respectively, comprising 86.1{\%} and 13.9{\%}, respectively, of the cohort. Limitations Retrospective study with potential for selection bias. Conclusion This index stratifies the risk of advanced adenoma on the second surveillance colonoscopy. If validated independently, it may be useful for tailoring surveillance.",
keywords = "Abbreviations, CI, confidence interval, SD, standard deviation",
author = "Thomas Imperiale and Ravi Juluri and Sherer, {Eric A.} and Glowinski, {Elizabeth A.} and Johnson, {Cynthia S.} and Morelli, {Michael S.}",
year = "2014",
doi = "10.1016/j.gie.2014.03.042",
language = "English",
volume = "80",
pages = "471--478",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps

AU - Imperiale, Thomas

AU - Juluri, Ravi

AU - Sherer, Eric A.

AU - Glowinski, Elizabeth A.

AU - Johnson, Cynthia S.

AU - Morelli, Michael S.

PY - 2014

Y1 - 2014

N2 - Background Predicting the risk of advanced colorectal neoplasia on the second surveillance colonoscopy could help tailor surveillance. Objective To derive and validate a risk index for advanced neoplasia on the second surveillance colonoscopy. Design Retrospective cohort. Setting Single-specialty practice; Veterans Affairs Medical Center. Patients A total of 965 patients with baseline adenomatous polyps, 2 surveillance colonoscopies, and no reported family history of colorectal cancer; validation cohort of 372. Interventions Multivariable logistic regression including demographics and previous colonoscopy results; derivation and validation of a risk index. Main Outcome Measurements Advanced adenoma (≥1 cm in size, villous histology, or high-grade dysplasia) on the second surveillance colonoscopy. Results Mean age was 57.8 ± 9.8 years, 62% were men, and 36% had an advanced adenoma on the index colonoscopy. Associated with advanced adenoma on the second surveillance colonoscopy were age at index colonoscopy (scored 0 for younger than 55 years of age, 1 for 55-59 years of age, 2 for 60-64 years of age, and 3 for older than 65 years of age) and previous findings (non-neoplastic, nonadvanced, advanced [scored 0, 1, and 2, respectively]) on index colonoscopy and the first surveillance colonoscopy, with scores ranging from 1 to 7. Risks of advanced adenoma on the second surveillance colonoscopy with scores of 5 or less and more than 5 were 4.8% (95% confidence interval, 3.5%-6.4%) and 14.9% (95% confidence interval, 7.4%-25.7%), respectively, comprising 93% and 7%, respectively, of the cohort. Corresponding results in the validation cohort were 5.6% and 19.2%, respectively, comprising 86.1% and 13.9%, respectively, of the cohort. Limitations Retrospective study with potential for selection bias. Conclusion This index stratifies the risk of advanced adenoma on the second surveillance colonoscopy. If validated independently, it may be useful for tailoring surveillance.

AB - Background Predicting the risk of advanced colorectal neoplasia on the second surveillance colonoscopy could help tailor surveillance. Objective To derive and validate a risk index for advanced neoplasia on the second surveillance colonoscopy. Design Retrospective cohort. Setting Single-specialty practice; Veterans Affairs Medical Center. Patients A total of 965 patients with baseline adenomatous polyps, 2 surveillance colonoscopies, and no reported family history of colorectal cancer; validation cohort of 372. Interventions Multivariable logistic regression including demographics and previous colonoscopy results; derivation and validation of a risk index. Main Outcome Measurements Advanced adenoma (≥1 cm in size, villous histology, or high-grade dysplasia) on the second surveillance colonoscopy. Results Mean age was 57.8 ± 9.8 years, 62% were men, and 36% had an advanced adenoma on the index colonoscopy. Associated with advanced adenoma on the second surveillance colonoscopy were age at index colonoscopy (scored 0 for younger than 55 years of age, 1 for 55-59 years of age, 2 for 60-64 years of age, and 3 for older than 65 years of age) and previous findings (non-neoplastic, nonadvanced, advanced [scored 0, 1, and 2, respectively]) on index colonoscopy and the first surveillance colonoscopy, with scores ranging from 1 to 7. Risks of advanced adenoma on the second surveillance colonoscopy with scores of 5 or less and more than 5 were 4.8% (95% confidence interval, 3.5%-6.4%) and 14.9% (95% confidence interval, 7.4%-25.7%), respectively, comprising 93% and 7%, respectively, of the cohort. Corresponding results in the validation cohort were 5.6% and 19.2%, respectively, comprising 86.1% and 13.9%, respectively, of the cohort. Limitations Retrospective study with potential for selection bias. Conclusion This index stratifies the risk of advanced adenoma on the second surveillance colonoscopy. If validated independently, it may be useful for tailoring surveillance.

KW - Abbreviations

KW - CI

KW - confidence interval

KW - SD

KW - standard deviation

UR - http://www.scopus.com/inward/record.url?scp=84906316935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906316935&partnerID=8YFLogxK

U2 - 10.1016/j.gie.2014.03.042

DO - 10.1016/j.gie.2014.03.042

M3 - Article

C2 - 24890416

AN - SCOPUS:84906316935

VL - 80

SP - 471

EP - 478

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 3

ER -