A role for class-II major histocompatibility complex antigens in the regulation of myelopoiesis

H. E. Broxmeyer, B. Dupont

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Except for the genetic restriction studies, where the HLA class-II antigens are needed for communication between cells, it is not proven that the HLA class-II antigens on human cells and class-II antigens on mouse cells are needed for the actions of the iron-binding glycoproteins LF, TF and AIF. While it is clear that MHC class-II positive cells are targets for these suppressor molecules and that there is a very tight association between the presence of these antigens on the specific target cells and the action of these iron-binding glycoproteins, further studies are needed to determine what role, if any, the MHC class-II antigens may play in this regulatory interaction for myelopoiesis in vitro. It is clear that the presence of class-II antigens on the different target cells for LF, TF and AIF preclude the possibility that they are specific receptors for these molecules. In addition to class-II antigens, the target cells must have specific receptors for LF, TF, or AIF. The possibility exists that Ia antigens may be needed for movement of LF, TF and AIF into the cells and/or that they may serve as a messenger link between the triggering event on the cell surface and the actual mechanisms that lead eventually to the suppressive events noted. If class-II antigens are involved in the functional actions of LF, TF and AIF at the cell surface, it would indicate that Ia antigens might serve a role in addition to their functions as an antigen-presenting molecule. Alternatively, more precise separation of subpopulations of cells may demonstrate that the actions of LF, TF and AIF involve cell-cell interactions and that the class-II antigens are involved intimately in a molecule-cell-cell interaction.

Original languageEnglish (US)
Pages (from-to)203-221
Number of pages19
JournalProgress in Allergy
VolumeVOL. 36
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy

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