A role for NADPH oxidase in antigen presentation

Gail J. Gardiner, Sarah N. Deffit, Shawna McLetchie, Liliana Pérez, Crystal C. Walline, Janice S. Blum

Research output: Contribution to journalShort survey

24 Scopus citations

Abstract

The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen species needed for microbicidal activity during innate immune responses. Inherited defects in NADPH oxidase give rise to chronic granulomatous disease (CGD), a primary immunodeficiency characterized by recurrent infections and granulomatous inflammation. Interestingly, CGD, CGD carrier status, and oxidase gene polymorphisms have all been associated with autoinflammatory and autoimmune disorders, suggesting a potential role for NADPH oxidase in regulating adaptive immune responses. Here, NADPH oxidase function in antigen processing and presentation is reviewed. NADPH oxidase influences dendritic cell (DC) crosspresentation by major histocompatibility complex class I molecules through regulation of the phagosomal microenvironment, while in B lymphocytes, NADPH oxidase alters epitope selection by major histocompatibility complex class II molecules.

Original languageEnglish (US)
Article numberArticle 295
JournalFrontiers in immunology
Volume4
Issue numberSEP
DOIs
StatePublished - 2013

Keywords

  • Antigen presentation
  • Autoimmunity
  • B lymphocytes
  • Chronic granulomatous disease
  • NADPH oxidase

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'A role for NADPH oxidase in antigen presentation'. Together they form a unique fingerprint.

  • Cite this

    Gardiner, G. J., Deffit, S. N., McLetchie, S., Pérez, L., Walline, C. C., & Blum, J. S. (2013). A role for NADPH oxidase in antigen presentation. Frontiers in immunology, 4(SEP), [Article 295]. https://doi.org/10.3389/fimmu.2013.00295