A role for NADPH oxidase in antigen presentation

Gail J. Gardiner, Sarah N. Deffit, Shawna McLetchie, Liliana Pérez, Crystal C. Walline, Janice S. Blum

Research output: Contribution to journalShort survey

24 Scopus citations


The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen species needed for microbicidal activity during innate immune responses. Inherited defects in NADPH oxidase give rise to chronic granulomatous disease (CGD), a primary immunodeficiency characterized by recurrent infections and granulomatous inflammation. Interestingly, CGD, CGD carrier status, and oxidase gene polymorphisms have all been associated with autoinflammatory and autoimmune disorders, suggesting a potential role for NADPH oxidase in regulating adaptive immune responses. Here, NADPH oxidase function in antigen processing and presentation is reviewed. NADPH oxidase influences dendritic cell (DC) crosspresentation by major histocompatibility complex class I molecules through regulation of the phagosomal microenvironment, while in B lymphocytes, NADPH oxidase alters epitope selection by major histocompatibility complex class II molecules.

Original languageEnglish (US)
Article numberArticle 295
JournalFrontiers in immunology
Issue numberSEP
StatePublished - 2013


  • Antigen presentation
  • Autoimmunity
  • B lymphocytes
  • Chronic granulomatous disease
  • NADPH oxidase

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Gardiner, G. J., Deffit, S. N., McLetchie, S., Pérez, L., Walline, C. C., & Blum, J. S. (2013). A role for NADPH oxidase in antigen presentation. Frontiers in immunology, 4(SEP), [Article 295]. https://doi.org/10.3389/fimmu.2013.00295