A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat

T. A. Hamilton, R. K. Handa, J. W. Harding, J. W. Wright

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Angiotensin II (AngII) or Angiotensin IV (AngIV) was infused into the renal artery of anesthetized rats while renal cortical blood flow was measured via laser Doppler flowmetry. The infusion of AngII produced a significant elevation in mean arterial pressure (MAP) with an accompanying decrease in cortical blood flow, glomerular filtration rate (GFR), urine volume, and urine sodium excretion. The infusion of AngIV induced significant increases in renal cortical blood flow and urine sodium excretion, without altering MAP, GFR, and urine volume. Pretreatment infusion with a specific AT1 receptor antagonist, DuP 753, blocked or attenuated the subsequent AngII effects, while pretreatment infusion with the specific AT4 receptor antagonist, Divalinal-AngIV, blocked the AngIV effects. These results support distinct and opposite roles for AngII and AngIV, i.e. AngII acts as an anti-natriuretic agent, while AngIV acts as a natriuretic agent.

Original languageEnglish (US)
Pages (from-to)935-944
Number of pages10
JournalPeptides
Volume22
Issue number6
DOIs
StatePublished - Jun 21 2001

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Keywords

  • AT receptor
  • AT receptor
  • Angiotensin II
  • Angiotensin IV
  • Divalinal-AngIV
  • DuP 753
  • Glomerular filtration rate
  • Kidney cortical blood flow
  • Urine sodium excretion

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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