A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis

Dongsheng Gu, Qipeng Fan, Xiaoli Zhang, Jingwu Xie

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Activated Hh signaling drives skin cancer development. Results: Activated Hh signaling in mice increases IL-11, IL-11Ra, and STAT3 phosphorylation. STAT3 or IL-11Ra knockout reduces SmoM2-mediated carcinogenesis. The Smo agonist alone induces STAT3 phosphorylation in an IL11Ra-dependent manner. Conclusion: The IL-11Ra/STAT3 signaling axis is required for Hh-mediated carcinogenesis. Significance: This is the first report to link STAT3 signaling to Hh-mediated carcinogenesis.

Original languageEnglish (US)
Pages (from-to)38356-38366
Number of pages11
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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