A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis

Dongsheng Gu, Qipeng Fan, Xiaoli Zhang, Jingwu Xie

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Activated Hh signaling drives skin cancer development. Results: Activated Hh signaling in mice increases IL-11, IL-11Ra, and STAT3 phosphorylation. STAT3 or IL-11Ra knockout reduces SmoM2-mediated carcinogenesis. The Smo agonist alone induces STAT3 phosphorylation in an IL11Ra-dependent manner. Conclusion: The IL-11Ra/STAT3 signaling axis is required for Hh-mediated carcinogenesis. Significance: This is the first report to link STAT3 signaling to Hh-mediated carcinogenesis.

Original languageEnglish
Pages (from-to)38356-38366
Number of pages11
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

Fingerprint

STAT3 Transcription Factor
Oncogenes
Carcinogenesis
Phosphorylation
Interleukin-11
Skin Neoplasms
Skin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. / Gu, Dongsheng; Fan, Qipeng; Zhang, Xiaoli; Xie, Jingwu.

In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 38356-38366.

Research output: Contribution to journalArticle

Gu, Dongsheng ; Fan, Qipeng ; Zhang, Xiaoli ; Xie, Jingwu. / A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 45. pp. 38356-38366.
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