A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis

D. M. Williams, D. M. Magee, Lynda Bonewald, J. G. Smith, C. A. Bleicker, G. I. Byrne, J. Schachter

Research output: Contribution to journalArticle

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Abstract

In a mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]), tumor necrosis factor alpha (TNF-α) antigen and bioactivity were demonstrated in vivo in the lung during MoPn infection in both athymic (nude) and heterozygous (nu/+) mice. Antibody to TNF-α that was exogenously given neutralized the TNF-α in the lung, significantly accelerated mortality, and caused a borderline increase in MoPn counts in the lung by culture in nu/+ mice. Lipopolysaccharide-induced TNF-α activity of injections of recombinant murine TNF-α significantly but modestly protected nu/+ mice against MoPn-induced mortality. TNF-α is produced in vivo during C. trachomatis infection and plays a role in host defense.

Original languageEnglish (US)
Pages (from-to)1572-1576
Number of pages5
JournalInfection and Immunity
Volume58
Issue number6
StatePublished - 1990
Externally publishedYes

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Chlamydia trachomatis
Tumor Necrosis Factor-alpha
Pneumonia
Lung
Chlamydia Infections
Mortality
Lipopolysaccharides
Antigens
Injections
Antibodies
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Williams, D. M., Magee, D. M., Bonewald, L., Smith, J. G., Bleicker, C. A., Byrne, G. I., & Schachter, J. (1990). A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis. Infection and Immunity, 58(6), 1572-1576.

A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis. / Williams, D. M.; Magee, D. M.; Bonewald, Lynda; Smith, J. G.; Bleicker, C. A.; Byrne, G. I.; Schachter, J.

In: Infection and Immunity, Vol. 58, No. 6, 1990, p. 1572-1576.

Research output: Contribution to journalArticle

Williams, DM, Magee, DM, Bonewald, L, Smith, JG, Bleicker, CA, Byrne, GI & Schachter, J 1990, 'A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis', Infection and Immunity, vol. 58, no. 6, pp. 1572-1576.
Williams DM, Magee DM, Bonewald L, Smith JG, Bleicker CA, Byrne GI et al. A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis. Infection and Immunity. 1990;58(6):1572-1576.
Williams, D. M. ; Magee, D. M. ; Bonewald, Lynda ; Smith, J. G. ; Bleicker, C. A. ; Byrne, G. I. ; Schachter, J. / A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis. In: Infection and Immunity. 1990 ; Vol. 58, No. 6. pp. 1572-1576.
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