A sensitivity analysis using alternative toxic equivalency factors to estimate U.S. dietary exposures to dioxin-like compounds

​Shahid  ​Parvez, Amanda M. Evans, Matthew Lorber, Belinda S. Hawkins, Jeffery C. Swartout, Linda K. Teuschler, Glenn E. Rice

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

EPA recommends sensitivity analyses when applying the toxic equivalency factor (TEF) method to evaluate exposures to dioxin-like compounds (DLCs). Applying the World Health Organization's (WHO) 2005 TEF values and estimating average U.S. daily dietary intakes of 25 DLCs from eight food categories, we estimate a toxic equivalency (TEQ) intake of 23. pg/day. Among DLCs, PCB 126 (26%) and 1,2,3,7,8-PeCDD (23%) dominate TEQ intakes. Among food categories, milk (14%), other dairy (28%), beef (25%), and seafood (18%) most influenced TEQ intakes. We develop two approaches to estimate alternative TEF values. Based on WHO's assumption regarding TEF uncertainty, Approach1 estimates upper and lower TEFs for each DLC by multiplying and dividing, respectively, its individual TEF by. ±. half a log. Based on compiled empirical ranges of relative potency estimates, Approach2 uses percentile values for individual TEFs. Total TEQ intake estimates using the lower and upper TEFs based on Approach1 were 8 and 68. pg TEQ/day, respectively. The 25th and 75th percentile TEFs from Approach2 yielded 12 and 28. pg TEQ/day, respectively. The influential DLCs and food categories remained consistent across alternative TEFs, except at the 90th percentile using Approach2. We highlight the need for developing underlying TEF probability distributions.

Original languageEnglish (US)
Pages (from-to)278-284
Number of pages7
JournalRegulatory Toxicology and Pharmacology
Volume67
Issue number2
DOIs
StatePublished - Nov 1 2013

Fingerprint

Dioxins
Poisons
Sensitivity analysis
3,4,5,3',4'-pentachlorobiphenyl
Food
Beef
Seafood
Dairies
Probability distributions
Uncertainty
Milk
Health

Keywords

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
  • Dietary intake
  • Dioxin-like compounds (DLCs)
  • Dose addition
  • Relative estimates of potency (REP)
  • Sensitivity analysis
  • Toxic equivalency (TEQ)
  • Toxic equivalency factor (TEF)

ASJC Scopus subject areas

  • Toxicology

Cite this

A sensitivity analysis using alternative toxic equivalency factors to estimate U.S. dietary exposures to dioxin-like compounds. / ​Parvez, ​Shahid ; Evans, Amanda M.; Lorber, Matthew; Hawkins, Belinda S.; Swartout, Jeffery C.; Teuschler, Linda K.; Rice, Glenn E.

In: Regulatory Toxicology and Pharmacology, Vol. 67, No. 2, 01.11.2013, p. 278-284.

Research output: Contribution to journalArticle

​Parvez, ​Shahid  ; Evans, Amanda M. ; Lorber, Matthew ; Hawkins, Belinda S. ; Swartout, Jeffery C. ; Teuschler, Linda K. ; Rice, Glenn E. / A sensitivity analysis using alternative toxic equivalency factors to estimate U.S. dietary exposures to dioxin-like compounds. In: Regulatory Toxicology and Pharmacology. 2013 ; Vol. 67, No. 2. pp. 278-284.
@article{140d1f7510c94f71bf8a64b44b115ab0,
title = "A sensitivity analysis using alternative toxic equivalency factors to estimate U.S. dietary exposures to dioxin-like compounds",
abstract = "EPA recommends sensitivity analyses when applying the toxic equivalency factor (TEF) method to evaluate exposures to dioxin-like compounds (DLCs). Applying the World Health Organization's (WHO) 2005 TEF values and estimating average U.S. daily dietary intakes of 25 DLCs from eight food categories, we estimate a toxic equivalency (TEQ) intake of 23. pg/day. Among DLCs, PCB 126 (26{\%}) and 1,2,3,7,8-PeCDD (23{\%}) dominate TEQ intakes. Among food categories, milk (14{\%}), other dairy (28{\%}), beef (25{\%}), and seafood (18{\%}) most influenced TEQ intakes. We develop two approaches to estimate alternative TEF values. Based on WHO's assumption regarding TEF uncertainty, Approach1 estimates upper and lower TEFs for each DLC by multiplying and dividing, respectively, its individual TEF by. ±. half a log. Based on compiled empirical ranges of relative potency estimates, Approach2 uses percentile values for individual TEFs. Total TEQ intake estimates using the lower and upper TEFs based on Approach1 were 8 and 68. pg TEQ/day, respectively. The 25th and 75th percentile TEFs from Approach2 yielded 12 and 28. pg TEQ/day, respectively. The influential DLCs and food categories remained consistent across alternative TEFs, except at the 90th percentile using Approach2. We highlight the need for developing underlying TEF probability distributions.",
keywords = "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), Dietary intake, Dioxin-like compounds (DLCs), Dose addition, Relative estimates of potency (REP), Sensitivity analysis, Toxic equivalency (TEQ), Toxic equivalency factor (TEF)",
author = "​Shahid  ​Parvez and Evans, {Amanda M.} and Matthew Lorber and Hawkins, {Belinda S.} and Swartout, {Jeffery C.} and Teuschler, {Linda K.} and Rice, {Glenn E.}",
year = "2013",
month = "11",
day = "1",
doi = "10.1016/j.yrtph.2013.08.007",
language = "English (US)",
volume = "67",
pages = "278--284",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - A sensitivity analysis using alternative toxic equivalency factors to estimate U.S. dietary exposures to dioxin-like compounds

AU - ​Parvez, ​Shahid 

AU - Evans, Amanda M.

AU - Lorber, Matthew

AU - Hawkins, Belinda S.

AU - Swartout, Jeffery C.

AU - Teuschler, Linda K.

AU - Rice, Glenn E.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - EPA recommends sensitivity analyses when applying the toxic equivalency factor (TEF) method to evaluate exposures to dioxin-like compounds (DLCs). Applying the World Health Organization's (WHO) 2005 TEF values and estimating average U.S. daily dietary intakes of 25 DLCs from eight food categories, we estimate a toxic equivalency (TEQ) intake of 23. pg/day. Among DLCs, PCB 126 (26%) and 1,2,3,7,8-PeCDD (23%) dominate TEQ intakes. Among food categories, milk (14%), other dairy (28%), beef (25%), and seafood (18%) most influenced TEQ intakes. We develop two approaches to estimate alternative TEF values. Based on WHO's assumption regarding TEF uncertainty, Approach1 estimates upper and lower TEFs for each DLC by multiplying and dividing, respectively, its individual TEF by. ±. half a log. Based on compiled empirical ranges of relative potency estimates, Approach2 uses percentile values for individual TEFs. Total TEQ intake estimates using the lower and upper TEFs based on Approach1 were 8 and 68. pg TEQ/day, respectively. The 25th and 75th percentile TEFs from Approach2 yielded 12 and 28. pg TEQ/day, respectively. The influential DLCs and food categories remained consistent across alternative TEFs, except at the 90th percentile using Approach2. We highlight the need for developing underlying TEF probability distributions.

AB - EPA recommends sensitivity analyses when applying the toxic equivalency factor (TEF) method to evaluate exposures to dioxin-like compounds (DLCs). Applying the World Health Organization's (WHO) 2005 TEF values and estimating average U.S. daily dietary intakes of 25 DLCs from eight food categories, we estimate a toxic equivalency (TEQ) intake of 23. pg/day. Among DLCs, PCB 126 (26%) and 1,2,3,7,8-PeCDD (23%) dominate TEQ intakes. Among food categories, milk (14%), other dairy (28%), beef (25%), and seafood (18%) most influenced TEQ intakes. We develop two approaches to estimate alternative TEF values. Based on WHO's assumption regarding TEF uncertainty, Approach1 estimates upper and lower TEFs for each DLC by multiplying and dividing, respectively, its individual TEF by. ±. half a log. Based on compiled empirical ranges of relative potency estimates, Approach2 uses percentile values for individual TEFs. Total TEQ intake estimates using the lower and upper TEFs based on Approach1 were 8 and 68. pg TEQ/day, respectively. The 25th and 75th percentile TEFs from Approach2 yielded 12 and 28. pg TEQ/day, respectively. The influential DLCs and food categories remained consistent across alternative TEFs, except at the 90th percentile using Approach2. We highlight the need for developing underlying TEF probability distributions.

KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

KW - Dietary intake

KW - Dioxin-like compounds (DLCs)

KW - Dose addition

KW - Relative estimates of potency (REP)

KW - Sensitivity analysis

KW - Toxic equivalency (TEQ)

KW - Toxic equivalency factor (TEF)

UR - http://www.scopus.com/inward/record.url?scp=84886583519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886583519&partnerID=8YFLogxK

U2 - 10.1016/j.yrtph.2013.08.007

DO - 10.1016/j.yrtph.2013.08.007

M3 - Article

C2 - 23973911

AN - SCOPUS:84886583519

VL - 67

SP - 278

EP - 284

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

IS - 2

ER -