A sexually transmitted infection screening algorithm based on semiparametric regression models

Zhuokai Li, Hai Liu, Wanzhu Tu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sexually transmitted infections (STIs) with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis are among the most common infectious diseases in the United States, disproportionately affecting young women. Because a significant portion of the infections present no symptoms, infection control relies primarily on disease screening. However, universal STI screening in a large population can be expensive. In this paper, we propose a semiparametric model-based screening algorithm. The model quantifies organism-specific infection risks in individual subjects and accounts for the within-subject interdependence of the infection outcomes of different organisms and the serial correlations among the repeated assessments of the same organism. Bivariate thin-plate regression spline surfaces are incorporated to depict the concurrent influences of age and sexual partners on infection acquisition. Model parameters are estimated by using a penalized likelihood method. For inference, we develop a likelihood-based resampling procedure to compare the bivariate effect surfaces across outcomes. Simulation studies are conducted to evaluate the model fitting performance. A screening algorithm is developed using data collected from an epidemiological study of young women at increased risk of STIs. We present evidence that the three organisms have distinct age and partner effect patterns; for C. trachomatis, the partner effect is more pronounced in younger adolescents. Predictive performance of the proposed screening algorithm is assessed through a receiver operating characteristic analysis. We show that the model-based screening algorithm has excellent accuracy in identifying individuals at increased risk, and thus can be used to assist STI screening in clinical practice.

Original languageEnglish (US)
Pages (from-to)2844-2857
Number of pages14
JournalStatistics in Medicine
Volume34
Issue number20
DOIs
StatePublished - Sep 10 2015

Fingerprint

Semiparametric Regression Model
Sexually Transmitted Diseases
Screening
Infection
Chlamydia trachomatis
Trichomonas vaginalis
Neisseria gonorrhoeae
Sexual Partners
Infection Control
ROC Curve
Communicable Diseases
Epidemiologic Studies
Model-based
Regression Splines
Thin-plate Spline
Surface Effects
Penalized Likelihood
Serial Correlation
Likelihood Methods
Operating Characteristics

Keywords

  • Bivariate surfaces
  • Multiple binary outcomes
  • Penalized likelihood
  • Resampling
  • Splines

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

Cite this

A sexually transmitted infection screening algorithm based on semiparametric regression models. / Li, Zhuokai; Liu, Hai; Tu, Wanzhu.

In: Statistics in Medicine, Vol. 34, No. 20, 10.09.2015, p. 2844-2857.

Research output: Contribution to journalArticle

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