A short and efficient stereoselective synthesis of all four diastereomers of sphingosine

Jae Mok Lee, Hyun Suk Lim, Sung Kee Chung

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Practical syntheses of all four stereomers of sphingosine from serine have been achieved through highly diastereoselective reduction of the N-trityl protected α′-amino enone derivative 5 with NaBH4 and reduction of the free α′-amino enone derivative 7 with Zn(BH4)2.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalTetrahedron Asymmetry
Volume13
Issue number4
DOIs
StatePublished - Mar 22 2002
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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