A simple strategy for the construction of combinatorial cyclic peptoid libraries

Ji Hoon Lee, Amanda M. Meyer, Hyun-Suk Lim

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Here we describe a simple method that allows for rapid and easy sequence determination of cyclic peptoids. The key idea in this strategy is a post-screening "ring-opening" reaction to convert cyclic peptoids selected from a high-throughput screen into linear peptoids, which can be sequenced by tandem mass spectrometry. Thus, there is no need for encoding.

Original languageEnglish
Pages (from-to)8615-8617
Number of pages3
JournalChemical Communications
Volume46
Issue number45
DOIs
StatePublished - Dec 7 2010

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Peptoids
Mass spectrometry
Screening
Throughput

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

A simple strategy for the construction of combinatorial cyclic peptoid libraries. / Lee, Ji Hoon; Meyer, Amanda M.; Lim, Hyun-Suk.

In: Chemical Communications, Vol. 46, No. 45, 07.12.2010, p. 8615-8617.

Research output: Contribution to journalArticle

Lee, Ji Hoon ; Meyer, Amanda M. ; Lim, Hyun-Suk. / A simple strategy for the construction of combinatorial cyclic peptoid libraries. In: Chemical Communications. 2010 ; Vol. 46, No. 45. pp. 8615-8617.
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