A simple strategy for the construction of combinatorial cyclic peptoid libraries

Ji Hoon Lee, Amanda M. Meyer, Hyun Suk Lim

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Here we describe a simple method that allows for rapid and easy sequence determination of cyclic peptoids. The key idea in this strategy is a post-screening "ring-opening" reaction to convert cyclic peptoids selected from a high-throughput screen into linear peptoids, which can be sequenced by tandem mass spectrometry. Thus, there is no need for encoding.

Original languageEnglish (US)
Pages (from-to)8615-8617
Number of pages3
JournalChemical Communications
Volume46
Issue number45
DOIs
StatePublished - Dec 7 2010

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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