A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells

Andrea M. Patterson, Liqiong Liu, Carol H. Sampson, P. Artur Plett, Hongge Li, Pratibha Singh, Khalid S. Mohammad, Jonathan Hoggatt, Maegan L. Capitano, Christie Orschell, Louis M. Pelus

Research output: Contribution to journalArticle

Abstract

In this article, Pelus, Orschell, and colleagues demonstrate that dmPGE2 protection from lethal radiation preserves HSC numbers and repopulating capacity, which is associated with attenuation of HSC cycling and DNA damage accumulation within the first critical day. Genomically, dmPGE2 predominantly blocks HSC induction of p53-regulated apoptotic genes within 1 h of irradiation, altogether promoting hematopoietic recovery and survival.

Original languageEnglish (US)
Pages (from-to)358-373
Number of pages16
JournalStem Cell Reports
Volume15
Issue number2
DOIs
StatePublished - Aug 11 2020

Keywords

  • 16,16-dimethyl PGE
  • DNA damage
  • RNA sequencing
  • bone marrow
  • cell cycle
  • hematopoietic regeneration
  • p53
  • prostaglandin
  • radiation
  • stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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    Patterson, A. M., Liu, L., Sampson, C. H., Plett, P. A., Li, H., Singh, P., Mohammad, K. S., Hoggatt, J., Capitano, M. L., Orschell, C., & Pelus, L. M. (2020). A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells. Stem Cell Reports, 15(2), 358-373. https://doi.org/10.1016/j.stemcr.2020.07.004