A statistical method for determining the breakpoint of two lines

Richard H. Jones, Bruce A. Molitoris

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


A method is presented for determining the breakpoint of a line which suddenly changes slope at some unknown point. A statistical test is given for testing whether the broken line is a significantly better fit to the data than a single straight line. An approximate confidence interval can be obtained for the position of the breakpoint.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalAnalytical biochemistry
Issue number1
StatePublished - Aug 15 1984
Externally publishedYes


  • Hill plots
  • breakpoints
  • confidence intervals
  • statistical methods

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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