A stochastic model for assessing Chlamydia trachomatis transmission risk by using longitudinal observational data

Wanzhu Tu, Pulak Ghosh, Barry Katz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bacterium Chlamydia trachomatis causes genital chlamydia infection. Yet little is known about the efficiency of transmission of this organism. Ethical constraint against exposing healthy subjects to infected partners precludes the possibility of quantifying the risk of transmission through controlled experiments. This research proposes an alternative strategy that relies on observational data. Specifically, we present a stochastic model that treats longitudinally observed states of infection in a group of young women as a Markov process. The model proposed explicitly accommodates the parameters of Chlamydia trachomatis transmission, including per-encounter sexually transmitted infection acquisition risks, with and without condom protection, and the probability of antibiotic treatment failure. The male-to-female transmission probability of Chlamydia trachomatis is then estimated by combining the per-encounter disease acquisition risk and the organism's prevalence in the male partner population. The model proposed is fitted in a Bayesian computational framework.

Original languageEnglish
Pages (from-to)975-989
Number of pages15
JournalJournal of the Royal Statistical Society. Series A: Statistics in Society
Volume174
Issue number4
DOIs
StatePublished - Oct 2011

Fingerprint

Stochastic Model
Infection
Antibiotics
Bacteria
Markov Process
Disease
efficiency
cause
experiment
Stochastic model
Alternatives
Group
Model
Experiment
Acquisition
Organism

Keywords

  • Bacterial infection
  • Binary outcome
  • Longitudinal study
  • Markov chain Monte Carlo methods
  • Markov model
  • Observational data
  • Transmission probability

ASJC Scopus subject areas

  • Statistics and Probability
  • Economics and Econometrics
  • Social Sciences (miscellaneous)
  • Statistics, Probability and Uncertainty

Cite this

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abstract = "Bacterium Chlamydia trachomatis causes genital chlamydia infection. Yet little is known about the efficiency of transmission of this organism. Ethical constraint against exposing healthy subjects to infected partners precludes the possibility of quantifying the risk of transmission through controlled experiments. This research proposes an alternative strategy that relies on observational data. Specifically, we present a stochastic model that treats longitudinally observed states of infection in a group of young women as a Markov process. The model proposed explicitly accommodates the parameters of Chlamydia trachomatis transmission, including per-encounter sexually transmitted infection acquisition risks, with and without condom protection, and the probability of antibiotic treatment failure. The male-to-female transmission probability of Chlamydia trachomatis is then estimated by combining the per-encounter disease acquisition risk and the organism's prevalence in the male partner population. The model proposed is fitted in a Bayesian computational framework.",
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AU - Ghosh, Pulak

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