A stochastic model of age-related bone loss and fractures

A. Horsman, D. H. Marshall, Munro Peacock

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A stochastic model of age-related bone loss capable of predicting age-specific incidence of fractures has been implemented by Monte Carlo simulation. Each simulation involves aging a large cohort of individuals from 20 to 100 years. Every individual is randomly allocated a particular amount of bone as a young adult, an age of onset of bone loss, and parameter values that determine the subsequent bone loss. Fracture risk is assumed to be zero when the amount of bone is above a global threshold level, increasing progressively as the amount of bone falls below the threshold. From the individual fracture risks, a fracture subpopulation is identified and age-specific incidence evaluated numerically. By adjusting the model parameters, predicted and observed incidences of femoral neck fracture can be closely matched in both sexes by use of a linear function to describe age-related bone loss. For fracture of the distal radius, a close match can be achieved in women by use of an exponential function to describe the bone loss phase. In men, the incidence is independent of age; trauma, rather than the amount of bone in the forearm, appears to be the main determinant of fracture risk.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalClinical Orthopaedics and Related Research
VolumeNO. 195
StatePublished - 1985
Externally publishedYes

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Bone Fractures
Osteoporosis
Bone and Bones
Incidence
Radius Fractures
Femoral Neck Fractures
Age of Onset
Forearm
Young Adult
Wounds and Injuries

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

A stochastic model of age-related bone loss and fractures. / Horsman, A.; Marshall, D. H.; Peacock, Munro.

In: Clinical Orthopaedics and Related Research, Vol. NO. 195, 1985, p. 207-215.

Research output: Contribution to journalArticle

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