A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis

A. A. Maschan, E. V. Skorobogatova, E. V. Samotchatova, D. N. Balashov, M. I. Yourlova, Natalia Bogatcheva, E. D. Pashanov, P. E. Trakhtman, A. M. Timakov, A. G. Rumiantzev

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis. She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-α2b together with weekly rotational chemotherapy. Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved. The patient's second acceleration occurred 22 months after the CML diagnosis. The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2. In order to prevent GVHD, CsA alone was administered, 3 mg/kg i.v. per day for a total of 40 days. The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg. Engraftment occurred on day +35. Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the posttransplant period. No chronic GVHD occurred. The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalBone Marrow Transplantation
Volume25
Issue number2
StatePublished - 2000
Externally publishedYes

Fingerprint

Leukemia, Myeloid, Accelerated Phase
Blast Crisis
Fetal Blood
Transplants
Drug Therapy
Busulfan
Granulocyte-Macrophage Progenitor Cells
Chimerism
Melphalan
Cytarabine
Siblings
Cell Count
Chromosomes
Transplantation
Mothers
Tissue Donors
Parturition
RNA

Keywords

  • Blast crisis
  • Chronic myeloid leukemia
  • Cord blood transplantation
  • GVL effect

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Maschan, A. A., Skorobogatova, E. V., Samotchatova, E. V., Balashov, D. N., Yourlova, M. I., Bogatcheva, N., ... Rumiantzev, A. G. (2000). A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis. Bone Marrow Transplantation, 25(2), 213-215.

A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis. / Maschan, A. A.; Skorobogatova, E. V.; Samotchatova, E. V.; Balashov, D. N.; Yourlova, M. I.; Bogatcheva, Natalia; Pashanov, E. D.; Trakhtman, P. E.; Timakov, A. M.; Rumiantzev, A. G.

In: Bone Marrow Transplantation, Vol. 25, No. 2, 2000, p. 213-215.

Research output: Contribution to journalArticle

Maschan, AA, Skorobogatova, EV, Samotchatova, EV, Balashov, DN, Yourlova, MI, Bogatcheva, N, Pashanov, ED, Trakhtman, PE, Timakov, AM & Rumiantzev, AG 2000, 'A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis', Bone Marrow Transplantation, vol. 25, no. 2, pp. 213-215.
Maschan, A. A. ; Skorobogatova, E. V. ; Samotchatova, E. V. ; Balashov, D. N. ; Yourlova, M. I. ; Bogatcheva, Natalia ; Pashanov, E. D. ; Trakhtman, P. E. ; Timakov, A. M. ; Rumiantzev, A. G. / A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis. In: Bone Marrow Transplantation. 2000 ; Vol. 25, No. 2. pp. 213-215.
@article{0fad3fce4b5047919a8d47d93e5f8f7a,
title = "A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis",
abstract = "We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis. She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-α2b together with weekly rotational chemotherapy. Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved. The patient's second acceleration occurred 22 months after the CML diagnosis. The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2. In order to prevent GVHD, CsA alone was administered, 3 mg/kg i.v. per day for a total of 40 days. The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg. Engraftment occurred on day +35. Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the posttransplant period. No chronic GVHD occurred. The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.",
keywords = "Blast crisis, Chronic myeloid leukemia, Cord blood transplantation, GVL effect",
author = "Maschan, {A. A.} and Skorobogatova, {E. V.} and Samotchatova, {E. V.} and Balashov, {D. N.} and Yourlova, {M. I.} and Natalia Bogatcheva and Pashanov, {E. D.} and Trakhtman, {P. E.} and Timakov, {A. M.} and Rumiantzev, {A. G.}",
year = "2000",
language = "English (US)",
volume = "25",
pages = "213--215",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis

AU - Maschan, A. A.

AU - Skorobogatova, E. V.

AU - Samotchatova, E. V.

AU - Balashov, D. N.

AU - Yourlova, M. I.

AU - Bogatcheva, Natalia

AU - Pashanov, E. D.

AU - Trakhtman, P. E.

AU - Timakov, A. M.

AU - Rumiantzev, A. G.

PY - 2000

Y1 - 2000

N2 - We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis. She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-α2b together with weekly rotational chemotherapy. Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved. The patient's second acceleration occurred 22 months after the CML diagnosis. The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2. In order to prevent GVHD, CsA alone was administered, 3 mg/kg i.v. per day for a total of 40 days. The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg. Engraftment occurred on day +35. Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the posttransplant period. No chronic GVHD occurred. The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.

AB - We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis. She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-α2b together with weekly rotational chemotherapy. Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved. The patient's second acceleration occurred 22 months after the CML diagnosis. The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2. In order to prevent GVHD, CsA alone was administered, 3 mg/kg i.v. per day for a total of 40 days. The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg. Engraftment occurred on day +35. Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the posttransplant period. No chronic GVHD occurred. The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.

KW - Blast crisis

KW - Chronic myeloid leukemia

KW - Cord blood transplantation

KW - GVL effect

UR - http://www.scopus.com/inward/record.url?scp=0033973644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033973644&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 213

EP - 215

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 2

ER -