A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis

A. A. Maschan, E. V. Skorobogatova, E. V. Samotchatova, D. N. Balashov, M. I. Yourlova, N. I. Bogatcheva, E. D. Pashanov, P. E. Trakhtman, A. M. Timakov, A. G. Rumiantzev

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis. She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-α2b together with weekly rotational chemotherapy. Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved. The patient's second acceleration occurred 22 months after the CML diagnosis. The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2. In order to prevent GVHD, CsA alone was administered, 3 mg/kg i.v. per day for a total of 40 days. The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg. Engraftment occurred on day +35. Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the posttransplant period. No chronic GVHD occurred. The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalBone Marrow Transplantation
Volume25
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Blast crisis
  • Chronic myeloid leukemia
  • Cord blood transplantation
  • GVL effect

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Maschan, A. A., Skorobogatova, E. V., Samotchatova, E. V., Balashov, D. N., Yourlova, M. I., Bogatcheva, N. I., Pashanov, E. D., Trakhtman, P. E., Timakov, A. M., & Rumiantzev, A. G. (2000). A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis. Bone Marrow Transplantation, 25(2), 213-215. https://doi.org/10.1038/sj.bmt.1702105