A Systematic Review of miR-29 in Cancer

Jason J. Kwon, Tricia D. Factora, Shatovisha Dey, Janaiah Kota

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29’s functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29.

Original languageEnglish (US)
Pages (from-to)173-194
Number of pages22
JournalMolecular Therapy - Oncolytics
Volume12
DOIs
StatePublished - Mar 29 2019

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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