A systematic review of nonpharmacological and nonsurgical therapies for gastroesophageal reflux in infants

Aaron Carroll, Michelle M. Garrison, Dimitri A. Christakis

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: Nonpharmacological and nonsurgical measures are often recommended for gastroesophageal reflux disease (GERD) in infants, despite ambiguous supporting evidence. Objective: To conduct a systematic review of rigorously evaluated nonpharmacological and nonsurgical therapies for GERD in infants. Design/Methods: We searched online bibliographic databases, including MEDLINE, EMBASE, the Cochrane Collaboration and Clinical Trials Database, and alternative medicine databases for the terms gastroesophageal reflux and infants. We selected randomized controlled trials of nonpharmacological and nonsurgical GERD therapies in otherwise healthy infants. Data were extracted from the selected articles regarding reflux, emetic episodes and intraesophageal pH. Results: We identified 43 relevant studies, of which 10 met the selection criteria. These studies examined positioning, pacifier use, and feeding changes. Positioning at a 60° elevation in an infant seat was found to increase reflux compared with the prone position. No significant difference was shown between the flat and head-elevated prone positions. The impact of pacifier use on reflux frequency was equivocal and dependent on infant position. The protein content of formula was not found to affect reflux. Although no study demonstrated a significant reflux-reducing benefit of thickened infant foods compared with placebo, 1 study detected a significant benefit of formula thickened with carob bean gum compared with rice flour (pH

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalArchives of Pediatrics and Adolescent Medicine
Volume156
Issue number2
StatePublished - 2002
Externally publishedYes

Fingerprint

Gastroesophageal Reflux
Pacifiers
Prone Position
Therapeutics
Infant Food
Databases
Bibliographic Databases
Emetics
Flour
Complementary Therapies
MEDLINE
Patient Selection
Randomized Controlled Trials
Head
Placebos
Clinical Trials
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A systematic review of nonpharmacological and nonsurgical therapies for gastroesophageal reflux in infants. / Carroll, Aaron; Garrison, Michelle M.; Christakis, Dimitri A.

In: Archives of Pediatrics and Adolescent Medicine, Vol. 156, No. 2, 2002, p. 109-113.

Research output: Contribution to journalArticle

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