A Systematic Review of Nutritional Supplementation in HIV-Infected Children in Resource-Limited Settings

Megan McHenry, Avika Dixit, Rachel Vreeman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: In resource-limited settings, malnutrition is the major cause of death in young children, but the precise benefits of nutritional supplementation for HIV-infected children are not well understood. Methods: Two researchers reviewed studies conducted in low- or middle-income countries that involved macro- and micronutrient supplementation in HIV-infected individuals ≥18 years. Results: Fifteen studies focused on micronutrients, including vitamin A, zinc, multivitamins, and multiplemicronutrient supplementation. The 8 macronutrient studies focused on ready-to-use foods (4 studies), spirulina, whey protein, general food rations, and F75 and F100 starter formulas. Vitamin A was associated with improved mortality rates, ranging from 28% to 63%. Multiple-micronutrient supplementations were not associated with improvement of measured health outcomes. Ready-to-use foods were associated with improvement in certain anthropometrics. Conclusion: Periodic vitamin A supplementation is associated with reduced mortality. Macronutrient supplementation is linked to improved anthropometrics. More research is needed to determine how nutritional supplementation benefits this particularly vulnerable population.

Original languageEnglish
Pages (from-to)313-323
Number of pages11
JournalJournal of the International Association of Providers of AIDS Care
Volume14
Issue number4
DOIs
StatePublished - Jul 25 2015

Fingerprint

Micronutrients
Vitamin A
HIV
Food
Spirulina
Mortality
Vulnerable Populations
Malnutrition
Zinc
Cause of Death
Research Personnel
Health
Research

Keywords

  • AIDS
  • children
  • clinical outcomes
  • HIV
  • nutrition
  • nutritional supplementation

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

Cite this

A Systematic Review of Nutritional Supplementation in HIV-Infected Children in Resource-Limited Settings. / McHenry, Megan; Dixit, Avika; Vreeman, Rachel.

In: Journal of the International Association of Providers of AIDS Care, Vol. 14, No. 4, 25.07.2015, p. 313-323.

Research output: Contribution to journalArticle

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