A tale of motor neurons and CD4+ T cells: Moving forward by looking back

Abhirami Kannan Iyer, Kathryn J. Jones

Research output: Contribution to journalReview articlepeer-review


Amyotrophic lateral sclerosis (ALS) is a fatal progressive disorder characterized by the selective degeneration of motor neurons (MN). The impact of peripheral immune status on disease progression and MN survival is becoming increasingly recognized in the ALS research field. In this review, we briefly discuss findings from mouse models of peripheral nerve injury and immunodeficiency to understand how the immune system regulates MN survival. We extend these observations to similar studies in the widely used superoxide dismutase 1 (SOD1) mouse model of ALS. Last, we present future hypotheses to identify potential causative factors that lead to immune dysregulation in ALS. The lessons from preceding work in this area offer new exciting directions to bridge the gap in our current understanding of immune-mediated neuroprotection in ALS.

Original languageEnglish (US)
Pages (from-to)562-565
Number of pages4
JournalNeural Regeneration Research
Issue number4
StatePublished - Apr 2017


  • Amyotrophic lateral sclerosis (ALS)
  • CD4 T cells
  • Immune system
  • Motor neuron
  • Neuroprotection
  • SOD1 mice
  • Superoxide dismutase 1 (SOD1)

ASJC Scopus subject areas

  • Developmental Neuroscience

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