A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

Kavita Shah, Debomoy Lahiri

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cdk5, a cyclin-dependent kinase family member, is a global orchestrator of neuronal cytoskeletal dynamics. During embryogenesis, Cdk5 is indispensable for brain development. In adults, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes through long-term potentiation and long-term depression, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity becomes deregulated in various brain disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, attention-deficit hyperactivity disorder, epilepsy, schizophrenia, and ischemic stroke; these all result in profound remodeling of the neuronal cytoskeleton. This Commentary specifically focuses on the pleiotropic contribution of Cdk5 in regulating neuronal microtubule remodeling. Because the vast majority of the physiological substrates of Cdk5 are associated with the neuronal cytoskeleton, our emphasis is on the Cdk5 substrates, such as CRMP2, stathmin, drebrin, dixdc1, axin, MAP2, MAP1B, doublecortin, kinesin-5, and tau, that have allowed to unravel the molecular mechanisms through which Cdk5 exerts its divergent roles in regulating neuronal microtubule dynamics, both in healthy and disease states.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalMolecular Neurobiology
DOIs
StateAccepted/In press - Mar 5 2016

Fingerprint

Cytoskeleton
Microtubules
Neuronal Plasticity
Brain
Stathmin
Kinesin
Cyclin-Dependent Kinases
Long-Term Potentiation
Huntington Disease
Brain Diseases
Attention Deficit Disorder with Hyperactivity
Cognition
Substance-Related Disorders
Embryonic Development
Parkinson Disease
Epilepsy
Schizophrenia
Alzheimer Disease
Stroke
Learning

Keywords

  • Alzheimer disease
  • Cdk5
  • Cytoskeleton
  • Microtubules
  • Neurodegeneration
  • p25
  • p35

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

A Tale of the Good and Bad : Remodeling of the Microtubule Network in the Brain by Cdk5. / Shah, Kavita; Lahiri, Debomoy.

In: Molecular Neurobiology, 05.03.2016, p. 1-14.

Research output: Contribution to journalArticle

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