A translational behavioral model of mood-based impulsivity

Implications for substance abuse

Cassandra D. Gipson, Joshua S. Beckmann, Zachary Adams, Julie A. Marusich, Travis O. Nesland, Justin R. Yates, Thomas H. Kelly, Michael T. Bardo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalDrug and Alcohol Dependence
Volume122
Issue number1-2
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Fingerprint

Impulsive Behavior
Substance-Related Disorders
Rats
Reward
Self Report
Amphetamine
Sucrose
Frustration
Exanthema
Surveys and Questionnaires

Keywords

  • Amphetamine
  • Impulsivity
  • Negative urgency
  • Self-administration
  • Substance abuse
  • Translational research

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Gipson, C. D., Beckmann, J. S., Adams, Z., Marusich, J. A., Nesland, T. O., Yates, J. R., ... Bardo, M. T. (2012). A translational behavioral model of mood-based impulsivity: Implications for substance abuse. Drug and Alcohol Dependence, 122(1-2), 93-99. https://doi.org/10.1016/j.drugalcdep.2011.09.014

A translational behavioral model of mood-based impulsivity : Implications for substance abuse. / Gipson, Cassandra D.; Beckmann, Joshua S.; Adams, Zachary; Marusich, Julie A.; Nesland, Travis O.; Yates, Justin R.; Kelly, Thomas H.; Bardo, Michael T.

In: Drug and Alcohol Dependence, Vol. 122, No. 1-2, 01.04.2012, p. 93-99.

Research output: Contribution to journalArticle

Gipson, CD, Beckmann, JS, Adams, Z, Marusich, JA, Nesland, TO, Yates, JR, Kelly, TH & Bardo, MT 2012, 'A translational behavioral model of mood-based impulsivity: Implications for substance abuse', Drug and Alcohol Dependence, vol. 122, no. 1-2, pp. 93-99. https://doi.org/10.1016/j.drugalcdep.2011.09.014
Gipson, Cassandra D. ; Beckmann, Joshua S. ; Adams, Zachary ; Marusich, Julie A. ; Nesland, Travis O. ; Yates, Justin R. ; Kelly, Thomas H. ; Bardo, Michael T. / A translational behavioral model of mood-based impulsivity : Implications for substance abuse. In: Drug and Alcohol Dependence. 2012 ; Vol. 122, No. 1-2. pp. 93-99.
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