A twin study of cholinergic REM induction

John Nurnberger, N. Sitaram, E. S. Gershon, J. C. Gillin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Seven monozygotic twin pairs were found to display concordance for sensitivity to REM sleep induction by arecoline (intraclass correlation (r(i)) of 0.69, F = 5.35, p <0.02). The REM1-REM2 interval on the placebo night did not show significant concordance (r(i) = 0.05, F = 1.11, p = 0.44). Our previous study suggested that increased sensitivity to the muscarinic agonist arecoline, as measured by time to onset of the second REM period during sleep, may be an indicator of vulnerability to affective disorder. The present finding of twin concordance in response to arecoline suggests genetic variation in sensitivity of CNS muscarinic cholinergic receptors. Such increased sensitivity may play an etiologic role in affective disorder.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalBiological Psychiatry
Volume18
Issue number10
StatePublished - 1983
Externally publishedYes

Fingerprint

Arecoline
Twin Studies
Cholinergic Agents
Mood Disorders
Muscarinic Agonists
Monozygotic Twins
REM Sleep
Cholinergic Receptors
Muscarinic Receptors
Sleep
Placebos

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Nurnberger, J., Sitaram, N., Gershon, E. S., & Gillin, J. C. (1983). A twin study of cholinergic REM induction. Biological Psychiatry, 18(10), 1161-1165.

A twin study of cholinergic REM induction. / Nurnberger, John; Sitaram, N.; Gershon, E. S.; Gillin, J. C.

In: Biological Psychiatry, Vol. 18, No. 10, 1983, p. 1161-1165.

Research output: Contribution to journalArticle

Nurnberger, J, Sitaram, N, Gershon, ES & Gillin, JC 1983, 'A twin study of cholinergic REM induction', Biological Psychiatry, vol. 18, no. 10, pp. 1161-1165.
Nurnberger J, Sitaram N, Gershon ES, Gillin JC. A twin study of cholinergic REM induction. Biological Psychiatry. 1983;18(10):1161-1165.
Nurnberger, John ; Sitaram, N. ; Gershon, E. S. ; Gillin, J. C. / A twin study of cholinergic REM induction. In: Biological Psychiatry. 1983 ; Vol. 18, No. 10. pp. 1161-1165.
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