A twist of insight - The role of Twist-family bHLH factors in development

Ralston M. Barnes, Anthony Firulli

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creates a dynamic role for these bHLH proteins. We summarize in this review information on each Twist-family member concerning expression pattern, function, regulation, downstream targets, and interactions with other bHLH proteins. Additionally, we focus on the phospho-regulatory mechanisms that tightly control posttranslational modification of Twist-family member bHLH proteins.

Original languageEnglish
Pages (from-to)909-924
Number of pages16
JournalInternational Journal of Developmental Biology
Volume53
Issue number7
DOIs
StatePublished - 2009

Fingerprint

Basic Helix-Loop-Helix Transcription Factors
E-Box Elements
Post Translational Protein Processing

Keywords

  • Dimerization
  • Hand1
  • Hand2
  • Heart
  • Limb
  • Paraxis
  • Phosphoregulation
  • Scleraxis
  • Trophoblast
  • Twist1
  • Twist2

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Medicine(all)

Cite this

A twist of insight - The role of Twist-family bHLH factors in development. / Barnes, Ralston M.; Firulli, Anthony.

In: International Journal of Developmental Biology, Vol. 53, No. 7, 2009, p. 909-924.

Research output: Contribution to journalArticle

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