A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease

Natalie A. Duncan, William Kronenberger, Kisha C. Hampton, Ellen M. Bloom, Angeli G. Rampersad, Christopher P. Roberson, Amy D. Shapiro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Antibiotic prophylaxis is a mainstay in sickle cell disease management. However, adherence is estimated at only 66%. This study aimed to develop and validate a Sickle Cell Antibiotic Adherence Level Evaluation (SCAALE) to promote systematic and detailed adherence evaluation. Methods: A 28-item questionnaire was created, covering seven adherence areas. General Adherence Ratings from the parent and one health care provider and medication possession ratios were obtained as validation measures. Results: Internal consistency was very good to excellent for the total SCAALE (α=0.89) and four of the seven subscales. Correlations between SCAALE scores and validation measures were strong for the total SCAALE and five of the seven subscales. Conclusion: The SCAALE provides a detailed, quantitative, multidimensional, and global measurement of adherence and can promote clinical care and research.

Original languageEnglish (US)
Pages (from-to)983-992
Number of pages10
JournalPatient Preference and Adherence
Volume10
DOIs
StatePublished - Jun 8 2016

Fingerprint

prophylaxis
Antibiotic Prophylaxis
Sickle Cell Anemia
Disease
Anti-Bacterial Agents
evaluation
Disease Management
possession
Health Personnel
parents
medication
rating
health care
questionnaire
management
Research

Keywords

  • Compliance
  • Hemoglobinopathy
  • Newborn screening program
  • Penicillin prophylaxis
  • SCAALE
  • Sickle SAFE program

ASJC Scopus subject areas

  • Social Sciences (miscellaneous)
  • Medicine (miscellaneous)
  • Health Policy
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Duncan, N. A., Kronenberger, W., Hampton, K. C., Bloom, E. M., Rampersad, A. G., Roberson, C. P., & Shapiro, A. D. (2016). A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease. Patient Preference and Adherence, 10, 983-992. https://doi.org/10.2147/PPA.S103874

A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease. / Duncan, Natalie A.; Kronenberger, William; Hampton, Kisha C.; Bloom, Ellen M.; Rampersad, Angeli G.; Roberson, Christopher P.; Shapiro, Amy D.

In: Patient Preference and Adherence, Vol. 10, 08.06.2016, p. 983-992.

Research output: Contribution to journalArticle

Duncan, Natalie A. ; Kronenberger, William ; Hampton, Kisha C. ; Bloom, Ellen M. ; Rampersad, Angeli G. ; Roberson, Christopher P. ; Shapiro, Amy D. / A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease. In: Patient Preference and Adherence. 2016 ; Vol. 10. pp. 983-992.
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