A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia

Arun Srivastava, Nyla Heerema, Richard C. Lauer, Piruz Nahreini, H. Scott Boswell, Ronald Hoffman, Asok C. Antony

Research output: Contribution to journalArticle

6 Scopus citations


Nonrandom reciprocal translocations involving chromosomes #15 and #17 are characteristic anomalies in a great majority of cases of acute promyelocytic leukemia (APL). Other complex translocations in APL that invariably involve chromosome #17 also have been described. We describe a patient with clinical and morphologic characteristics of APL but with a previously undescribed acquired karyotype, t(X;15)(p11;q22). This is the first translocation in APL described in which chromosome #17 is not involved. Although a comparative structure/function analysis of potentially relevant genes to the translocation breakpoints in both t(X;15) and t(15;17) APL showed no major alterations, the enhanced expression of the c-Kiras oncogene observed in t(X;15) APL supports the concept of heterogeneity in APL at the cytogenetic and molecular levels.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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