A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Fabrizio Tagliavini, Giorgio Giaccone, Frances Prelli, Laura Verga, Monica Porro, John Q. Trojanowski, Martin Farlow, Blas Frangione, Bernardino Ghetti, Orso Bugiani

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Gerstmann-Sträussler-Scheinker disease in the Indiana kindred is pathologically characterized by prion protein amyloid deposits and neurofibrillary tangles (NFT) with paired helical filaments (PHF). Using antibodies to various domains of the tau molecule, we investigated the composition of PHF in this family by immunocytochemistry and immunoblot analysis. The results indicate that A68 is a component of NFT in this family as it is in Alzheimer's disease, and suggest that post-translational modifications of tau leading to formation of A68 are not unique to Alzheimer's disease.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalBrain Research
Volume616
Issue number1-2
DOIs
StatePublished - Jul 9 1993

Fingerprint

Neurofibrillary Tangles
Alzheimer Disease
Amyloid Plaques
Post Translational Protein Processing
Immunohistochemistry
Antibodies
Prion Proteins

Keywords

  • A68
  • Alzheimer's disease
  • Gerstmann-Sträussler-Scheinker disease
  • Neurofibrillary tangle
  • Paired helical filament
  • Protein tau

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tagliavini, F., Giaccone, G., Prelli, F., Verga, L., Porro, M., Trojanowski, J. Q., ... Bugiani, O. (1993). A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred. Brain Research, 616(1-2), 325-329. https://doi.org/10.1016/0006-8993(93)90226-D

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred. / Tagliavini, Fabrizio; Giaccone, Giorgio; Prelli, Frances; Verga, Laura; Porro, Monica; Trojanowski, John Q.; Farlow, Martin; Frangione, Blas; Ghetti, Bernardino; Bugiani, Orso.

In: Brain Research, Vol. 616, No. 1-2, 09.07.1993, p. 325-329.

Research output: Contribution to journalArticle

Tagliavini, F, Giaccone, G, Prelli, F, Verga, L, Porro, M, Trojanowski, JQ, Farlow, M, Frangione, B, Ghetti, B & Bugiani, O 1993, 'A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred', Brain Research, vol. 616, no. 1-2, pp. 325-329. https://doi.org/10.1016/0006-8993(93)90226-D
Tagliavini, Fabrizio ; Giaccone, Giorgio ; Prelli, Frances ; Verga, Laura ; Porro, Monica ; Trojanowski, John Q. ; Farlow, Martin ; Frangione, Blas ; Ghetti, Bernardino ; Bugiani, Orso. / A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred. In: Brain Research. 1993 ; Vol. 616, No. 1-2. pp. 325-329.
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