A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Fabrizio Tagliavini, Giorgio Giaccone, Frances Prelli, Laura Verga, Monica Porro, John Q. Trojanowski, Martin R. Farlow, Blas Frangione, Bernardino Ghetti, Orso Bugiani

Research output: Contribution to journalArticle

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Abstract

Gerstmann-Sträussler-Scheinker disease in the Indiana kindred is pathologically characterized by prion protein amyloid deposits and neurofibrillary tangles (NFT) with paired helical filaments (PHF). Using antibodies to various domains of the tau molecule, we investigated the composition of PHF in this family by immunocytochemistry and immunoblot analysis. The results indicate that A68 is a component of NFT in this family as it is in Alzheimer's disease, and suggest that post-translational modifications of tau leading to formation of A68 are not unique to Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalBrain research
Volume616
Issue number1-2
DOIs
StatePublished - Jul 9 1993

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Keywords

  • A68
  • Alzheimer's disease
  • Gerstmann-Sträussler-Scheinker disease
  • Neurofibrillary tangle
  • Paired helical filament
  • Protein tau

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tagliavini, F., Giaccone, G., Prelli, F., Verga, L., Porro, M., Trojanowski, J. Q., Farlow, M. R., Frangione, B., Ghetti, B., & Bugiani, O. (1993). A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred. Brain research, 616(1-2), 325-329. https://doi.org/10.1016/0006-8993(93)90226-D