Abdominal radical trachelectomy in West London

S. Saso, S. Ghaem-Maghami, J. Chatterjee, O. Naji, A. Farthing, P. Mason, A. McIndoe, V. Hird, L. Ungar, G. Del Priore, J. R. Smith

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective Traditionally, the surgical management of invasive cervical carcinoma that has progressed beyond microinvasion has been a radical abdominal hysterectomy. However, this results in the loss of fertility, with significant consequences for the young patient. This report describes abdominal radical trachelectomy (ART) as a potential replacement for radical hysterectomy in patients with stage IA2-IIA cervical cancer who desire a fertility-sparing procedure without decreasing the curative rates. Design Observational, retrospective study. Setting Teaching hospital and regional cancer centre in London, UK. Population Patients undergoing ART. Methods Patients presenting during the period 2000-2009 with cervical cancer stage IA2-IIA were offered a trachelectomy, if they expressed a desire to preserve fertility. The type of trachelectomy (vaginal/abdominal) was chosen based on patient anatomy and neoplastic and magnetic resonance imaging characteristics. Each patient was counselled as to the experimental nature of the procedure. Main outcome measures Survival, recurrence and fertility issues among ART patients. Results A total of 30 patients underwent ART (open and laparoscopic) between 2001 and 2009. Three patients presented with a recurrence, two of which have died (median follow-up: 24 months). Only three patients required further surgical re-intervention because of operative complications. Ten patients attempted to conceive, resulting in three conceptions (30%) and two live children. Conclusions Abdominal radical trachelectomy provides a feasible, cost-effective and safe treatment option for young women who have been diagnosed with early-stage cervical cancer and wish to preserve their fertility.

Original languageEnglish (US)
Pages (from-to)187-193
Number of pages7
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume119
Issue number2
DOIs
StatePublished - Jan 1 2012

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Fertility
Uterine Cervical Neoplasms
Hysterectomy
Trachelectomy
Recurrence
Teaching Hospitals
Observational Studies
Anatomy
Retrospective Studies
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Carcinoma
Costs and Cost Analysis
Survival
Population
Neoplasms
Therapeutics

Keywords

  • Cervical cancer
  • fertility
  • recurrence
  • survival
  • trachelectomy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Saso, S., Ghaem-Maghami, S., Chatterjee, J., Naji, O., Farthing, A., Mason, P., ... Smith, J. R. (2012). Abdominal radical trachelectomy in West London. BJOG: An International Journal of Obstetrics and Gynaecology, 119(2), 187-193. https://doi.org/10.1111/j.1471-0528.2011.03213.x

Abdominal radical trachelectomy in West London. / Saso, S.; Ghaem-Maghami, S.; Chatterjee, J.; Naji, O.; Farthing, A.; Mason, P.; McIndoe, A.; Hird, V.; Ungar, L.; Del Priore, G.; Smith, J. R.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 119, No. 2, 01.01.2012, p. 187-193.

Research output: Contribution to journalArticle

Saso, S, Ghaem-Maghami, S, Chatterjee, J, Naji, O, Farthing, A, Mason, P, McIndoe, A, Hird, V, Ungar, L, Del Priore, G & Smith, JR 2012, 'Abdominal radical trachelectomy in West London', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 119, no. 2, pp. 187-193. https://doi.org/10.1111/j.1471-0528.2011.03213.x
Saso S, Ghaem-Maghami S, Chatterjee J, Naji O, Farthing A, Mason P et al. Abdominal radical trachelectomy in West London. BJOG: An International Journal of Obstetrics and Gynaecology. 2012 Jan 1;119(2):187-193. https://doi.org/10.1111/j.1471-0528.2011.03213.x
Saso, S. ; Ghaem-Maghami, S. ; Chatterjee, J. ; Naji, O. ; Farthing, A. ; Mason, P. ; McIndoe, A. ; Hird, V. ; Ungar, L. ; Del Priore, G. ; Smith, J. R. / Abdominal radical trachelectomy in West London. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2012 ; Vol. 119, No. 2. pp. 187-193.
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