Aberrant Expression of the Myeloid Zinc Finger Gene, MZF-1, Is Oncogenic

Robert Hromas, Jennifer Morris, Kenneth Cornetta, Douglas Berebitsky, Amy Davidson, Michael Sha, George Sledge, Frank Rauscher

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoiesis. Regulators of development are potential targets for neoplastic transformation. This study investigated whether unregulated expression of MZF-1 could function as an oncogene. Retroviral transduction and subsequent overexpression of MZF-1 resulted in loss of contact inhibition, loss of substrate dependence, and more rapid cell cycling in NIH 3T3 cells. The MZF- 1-transformed 3T3 cells formed aggressive tumors in athymic mice. Disruption of the tight lineage- and stage-specific regulation of MZF-1 can result in neoplastic transformation of embryonic fibroblasts. Therefore, MZF-1 represents a novel oncogene.

Original languageEnglish (US)
Pages (from-to)3610-3614
Number of pages5
JournalCancer Research
Volume55
Issue number16
StatePublished - Aug 15 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hromas, R., Morris, J., Cornetta, K., Berebitsky, D., Davidson, A., Sha, M., Sledge, G., & Rauscher, F. (1995). Aberrant Expression of the Myeloid Zinc Finger Gene, MZF-1, Is Oncogenic. Cancer Research, 55(16), 3610-3614.