Aberrantly regulated proteins in frontotemporal dementia

Kelly Schweitzer, Emily Decker, Liping Zhu, Richard E. Miller, Suzanne S. Mirra, Salvatore Spina, Bernardino Ghetti, Mu Wang, Jill Murrell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

Original languageEnglish
Pages (from-to)465-472
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume348
Issue number2
DOIs
StatePublished - Sep 22 2006

Fingerprint

Frontotemporal Dementia
Ubiquitin Thiolesterase
Chromosomes, Human, Pair 17
Oxidative stress
Pathology
Chromosomes
Proteins
Oxidative Stress
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Electrophoresis, Gel, Two-Dimensional
Parkinsonian Disorders
Frontal Lobe
Ubiquitin
Electrophoresis
Proteomics
Dementia
Gels
Degradation

Keywords

  • Frontotemporal dementia and parkinsonism linked to chromosome 17
  • Matrix-assisted laser desorption/ionization time-of-flight
  • Oxidative stress
  • Two-dimensional electrophoresis
  • Ubiquitin C-terminal hydrolyase L1
  • UCHL1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Schweitzer, K., Decker, E., Zhu, L., Miller, R. E., Mirra, S. S., Spina, S., ... Murrell, J. (2006). Aberrantly regulated proteins in frontotemporal dementia. Biochemical and Biophysical Research Communications, 348(2), 465-472. https://doi.org/10.1016/j.bbrc.2006.07.113

Aberrantly regulated proteins in frontotemporal dementia. / Schweitzer, Kelly; Decker, Emily; Zhu, Liping; Miller, Richard E.; Mirra, Suzanne S.; Spina, Salvatore; Ghetti, Bernardino; Wang, Mu; Murrell, Jill.

In: Biochemical and Biophysical Research Communications, Vol. 348, No. 2, 22.09.2006, p. 465-472.

Research output: Contribution to journalArticle

Schweitzer, K, Decker, E, Zhu, L, Miller, RE, Mirra, SS, Spina, S, Ghetti, B, Wang, M & Murrell, J 2006, 'Aberrantly regulated proteins in frontotemporal dementia', Biochemical and Biophysical Research Communications, vol. 348, no. 2, pp. 465-472. https://doi.org/10.1016/j.bbrc.2006.07.113
Schweitzer, Kelly ; Decker, Emily ; Zhu, Liping ; Miller, Richard E. ; Mirra, Suzanne S. ; Spina, Salvatore ; Ghetti, Bernardino ; Wang, Mu ; Murrell, Jill. / Aberrantly regulated proteins in frontotemporal dementia. In: Biochemical and Biophysical Research Communications. 2006 ; Vol. 348, No. 2. pp. 465-472.
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