Aberrantly regulated proteins in frontotemporal dementia

Kelly Schweitzer, Emily Decker, Liping Zhu, Richard E. Miller, Suzanne S. Mirra, Salvatore Spina, Bernardino Ghetti, Mu Wang, Jill Murrell

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

Original languageEnglish (US)
Pages (from-to)465-472
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume348
Issue number2
DOIs
StatePublished - Sep 22 2006

    Fingerprint

Keywords

  • Frontotemporal dementia and parkinsonism linked to chromosome 17
  • Matrix-assisted laser desorption/ionization time-of-flight
  • Oxidative stress
  • Two-dimensional electrophoresis
  • Ubiquitin C-terminal hydrolyase L1
  • UCHL1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Schweitzer, K., Decker, E., Zhu, L., Miller, R. E., Mirra, S. S., Spina, S., Ghetti, B., Wang, M., & Murrell, J. (2006). Aberrantly regulated proteins in frontotemporal dementia. Biochemical and Biophysical Research Communications, 348(2), 465-472. https://doi.org/10.1016/j.bbrc.2006.07.113